Cargando…

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

A majority of cancers fail to respond to immunotherapy with antibodies targeting immune checkpoints, such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) or programmed death-1 (PD-1)/PD-1 ligand (PD-L1). Cancers frequently express transforming growth factor-β (TGFβ), which drives immune dysfunction in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ravi, Rajani, Noonan, Kimberly A., Pham, Vui, Bedi, Rishi, Zhavoronkov, Alex, Ozerov, Ivan V., Makarev, Eugene, V. Artemov, Artem, Wysocki, Piotr T., Mehra, Ranee, Nimmagadda, Sridhar, Marchionni, Luigi, Sidransky, David, Borrello, Ivan M., Izumchenko, Evgeny, Bedi, Atul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821872/ https://www.ncbi.nlm.nih.gov/pubmed/29467463 http://dx.doi.org/10.1038/s41467-017-02696-6

Ejemplares similares

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia
por: Makarev, Eugene, et al.
Publicado: (2017)

Common pathway signature in lung and liver fibrosis
por: Makarev, Eugene, et al.
Publicado: (2016)

Adenylate Kinase 3 Sensitizes Cells to Cigarette Smoke Condensate Vapor Induced Cisplatin Resistance
por: Chang, Xiaofei, et al.
Publicado: (2011)

Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients
por: Zhu, Qingsong, et al.
Publicado: (2015)

Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA
por: Izumchenko, Evgeny, et al.
Publicado: (2015)

In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
por: Ozerov, Ivan V., et al.
Publicado: (2016)

Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma
por: Zhavoronkov, Alex, et al.
Publicado: (2016)

High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders
por: Mkrtchyan, Garik V., et al.
Publicado: (2022)

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
por: Chao, Jaime L., et al.
Publicado: (2021)

Adenoid cystic carcinoma: emerging role of translocations and gene fusions
por: Wysocki, Piotr T., et al.
Publicado: (2016)

Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor
por: Solanki, Hitendra S., et al.
Publicado: (2018)

Correction: Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor
por: Solanki, Hitendra S., et al.
Publicado: (2021)

Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells
por: West, Michael D., et al.
Publicado: (2017)

Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma
por: Broner, Esther C., et al.
Publicado: (2021)

Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification
por: Mamoshina, Polina, et al.
Publicado: (2018)

NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
por: Peri, Suraj, et al.
Publicado: (2017)

Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions
por: Makarev, Evgeny, et al.
Publicado: (2014)

Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine
por: Pun, Frank W., et al.
Publicado: (2022)

The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase Inhibitors
por: Chang, Xiaofei, et al.
Publicado: (2013)

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization
por: Cortese, Franco, et al.
Publicado: (2018)

Islet1 and Its Co-Factor Ldb1 Are Expressed in Quiescent Cells of Mouse Intestinal Epithelium
por: Makarev, Evgeny, et al.
Publicado: (2014)

Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells
por: Makarev, Eugene, et al.
Publicado: (2015)

Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells
por: Pustovalova, Margarita, et al.
Publicado: (2017)

A review of water fluoridation implementation strategy in England 2002–2005
por: Wordley, V., et al.
Publicado: (2020)

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform
por: Pun, Frank W., et al.
Publicado: (2022)

COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity
por: Naumov, Vladimir, et al.
Publicado: (2021)

Marrow-Infiltrating Lymphocytes – Role in Biology and Cancer Therapy
por: Borrello, Ivan, et al.
Publicado: (2016)

Towards natural mimetics of metformin and rapamycin
por: Aliper, Alexander, et al.
Publicado: (2017)

Comparative mutational landscape analysis of patient-derived tumour xenografts
por: Brait, Mariana, et al.
Publicado: (2017)

Differential Expression of Chemokine Receptors and their Roles in Cancer Imaging
por: Nimmagadda, Sridhar
Publicado: (2012)

Quantifying PD-L1 Expression to Monitor Immune Checkpoint Therapy: Opportunities and Challenges
por: Nimmagadda, Sridhar
Publicado: (2020)

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state
por: Aliper, Alexander, et al.
Publicado: (2016)

Conservative and surgical management of foot and ankle sporting injuries in the weekend warrior
por: Bedi, Harvinder S
Publicado: (2011)

Re-emergence of Wild Polio Virus in East Mediterranean Region: A Threat to World Polio Eradication Program Initiatives?
por: Bedi, Neeraj
Publicado: (2014)

Medical Research Misconduct Need Regulatory Reforms
por: Bedi, Neeraj
Publicado: (2014)

The Hip Bone Is Connected to the Thigh Bone!
por: Bedi, Asheesh
Publicado: (2014)

Changing patient safety in India: Mandatory hepatitis B immunity
por: Bedi, Raman
Publicado: (2015)

The Sugar Tax: A Leadership Issue for the Dental Profession and An Opportunity to Demonstrate that Oral Health is Part of General Health
por: Bedi, Raman
Publicado: (2018)

Fake marriages, asylum, and gas station robberies: institutional determinants of migrants' strategies
por: Bedi, Joshua
Publicado: (2023)

Hierarchical confounder discovery in the experiment-machine learning cycle
por: Rogozhnikov, Alex, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6ans5h9556uv3693bmjfcrtsu1