Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context

Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of hepatocellular carcinoma. We found that the rate of R70Q/H in HCV 1b from Russia was 31.2%, similar to that in HCV strains from Asia (34.0%), highe...

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Detalles Bibliográficos
Autores principales: Kichatova, V. S., Kyuregyan, K. K., Soboleva, N. V., Karlsen, A. A., Isaeva, O. V., Isaguliants, M. G., Mikhailov, M. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821972/
https://www.ncbi.nlm.nih.gov/pubmed/29577052
http://dx.doi.org/10.1155/2018/7685371

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