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Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report

Background. Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies. The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been pre...

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Autores principales: Jaworek, Jolanta, Tudek, Barbara, Kowalczyk, Paweł, Kot, Michalina, Szklarczyk, Joanna, Leja-Szpak, Anna, Pierzchalski, Piotr, Bonior, Joanna, Dembiński, Artur, Ceranowicz, Piotr, Warzecha, Zygmunt, Nawrot-Porąbka, Katarzyna, Gil, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821989/
https://www.ncbi.nlm.nih.gov/pubmed/29576768
http://dx.doi.org/10.1155/2018/6915059
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author Jaworek, Jolanta
Tudek, Barbara
Kowalczyk, Paweł
Kot, Michalina
Szklarczyk, Joanna
Leja-Szpak, Anna
Pierzchalski, Piotr
Bonior, Joanna
Dembiński, Artur
Ceranowicz, Piotr
Warzecha, Zygmunt
Nawrot-Porąbka, Katarzyna
Gil, Krzysztof
author_facet Jaworek, Jolanta
Tudek, Barbara
Kowalczyk, Paweł
Kot, Michalina
Szklarczyk, Joanna
Leja-Szpak, Anna
Pierzchalski, Piotr
Bonior, Joanna
Dembiński, Artur
Ceranowicz, Piotr
Warzecha, Zygmunt
Nawrot-Porąbka, Katarzyna
Gil, Krzysztof
author_sort Jaworek, Jolanta
collection PubMed
description Background. Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies. The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been previously explored. We present the impact of neonatal endotoxemia on the pancreatic exocrine function and on the acute pancreatitis which has been investigated in the adult animals. Endotoxemia was induced in suckling rats by intraperitoneal application of LPS from Escherichia coli or Salmonella typhi. In the adult rats, pretreated in the early period of life with LPS, histological manifestations of acute pancreatitis have been reduced. Pancreatic weight and plasma lipase activity were decreased, and SOD concentration was reversed and accompanied by a significant reduction of lipid peroxidation products (MDA + 4 HNE) in the pancreatic tissue. In the pancreatic acini, the significant increases in protein signals for toll-like receptor 4 and for heat shock protein 60 were found. Signal for the CCK1 receptor was reduced and pancreatic secretory responses to caerulein were diminished, whereas basal enzyme secretion was unaffected. These pioneer studies have shown that exposition of suckling rats to endotoxin has an impact on the pancreas in the adult organism.
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spelling pubmed-58219892018-03-25 Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report Jaworek, Jolanta Tudek, Barbara Kowalczyk, Paweł Kot, Michalina Szklarczyk, Joanna Leja-Szpak, Anna Pierzchalski, Piotr Bonior, Joanna Dembiński, Artur Ceranowicz, Piotr Warzecha, Zygmunt Nawrot-Porąbka, Katarzyna Gil, Krzysztof Gastroenterol Res Pract Review Article Background. Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies. The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been previously explored. We present the impact of neonatal endotoxemia on the pancreatic exocrine function and on the acute pancreatitis which has been investigated in the adult animals. Endotoxemia was induced in suckling rats by intraperitoneal application of LPS from Escherichia coli or Salmonella typhi. In the adult rats, pretreated in the early period of life with LPS, histological manifestations of acute pancreatitis have been reduced. Pancreatic weight and plasma lipase activity were decreased, and SOD concentration was reversed and accompanied by a significant reduction of lipid peroxidation products (MDA + 4 HNE) in the pancreatic tissue. In the pancreatic acini, the significant increases in protein signals for toll-like receptor 4 and for heat shock protein 60 were found. Signal for the CCK1 receptor was reduced and pancreatic secretory responses to caerulein were diminished, whereas basal enzyme secretion was unaffected. These pioneer studies have shown that exposition of suckling rats to endotoxin has an impact on the pancreas in the adult organism. Hindawi 2018-01-14 /pmc/articles/PMC5821989/ /pubmed/29576768 http://dx.doi.org/10.1155/2018/6915059 Text en Copyright © 2018 Jolanta Jaworek et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jaworek, Jolanta
Tudek, Barbara
Kowalczyk, Paweł
Kot, Michalina
Szklarczyk, Joanna
Leja-Szpak, Anna
Pierzchalski, Piotr
Bonior, Joanna
Dembiński, Artur
Ceranowicz, Piotr
Warzecha, Zygmunt
Nawrot-Porąbka, Katarzyna
Gil, Krzysztof
Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
title Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
title_full Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
title_fullStr Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
title_full_unstemmed Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
title_short Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
title_sort effect of endotoxemia in suckling rats on pancreatic integrity and exocrine function in adults: a review report
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821989/
https://www.ncbi.nlm.nih.gov/pubmed/29576768
http://dx.doi.org/10.1155/2018/6915059
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