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Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012
BACKGROUND: Lower lip squamous cell carcinoma (LLSCC) is a common malignancy of the head and neck, being mainly a consequence of a chronic exposure to ultraviolet (UV) light solar radiation. Here, we evaluated the clinicopathological profile of patients with photosensitive disorders (xeroderma pigme...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822543/ https://www.ncbi.nlm.nih.gov/pubmed/29274161 http://dx.doi.org/10.4317/medoral.21960 |
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author | Borges, Jorena-Fraga-Pimenta Lanaro, Nattália-Di Bernardo, Vagner-Gonçalves Albano, Rodolpho-Mattos Dias, Fernando de Faria, Paulo-Antônio-Silvestre Pinto, Luis-Felipe-Ribeiro Lourenço, Simone-de Queiroz-Chaves |
author_facet | Borges, Jorena-Fraga-Pimenta Lanaro, Nattália-Di Bernardo, Vagner-Gonçalves Albano, Rodolpho-Mattos Dias, Fernando de Faria, Paulo-Antônio-Silvestre Pinto, Luis-Felipe-Ribeiro Lourenço, Simone-de Queiroz-Chaves |
author_sort | Borges, Jorena-Fraga-Pimenta |
collection | PubMed |
description | BACKGROUND: Lower lip squamous cell carcinoma (LLSCC) is a common malignancy of the head and neck, being mainly a consequence of a chronic exposure to ultraviolet (UV) light solar radiation. Here, we evaluated the clinicopathological profile of patients with photosensitive disorders (xeroderma pigmentosum, lupus erythematosus and albinism) that developed LLSCC. MATERIAL AND METHODS: Data from patients who had a diagnosed LLSCC with a prior xeroderma pigmentosum, lupus erythematosus or albinism diagnosis that were treated at INCA from 1999 to 2012 were collected from patients’ medical records (n=16). The control group was composed of 68 patients with LLSCC without a medical history of photosensitivity. The clinicopathological data of this study population were collected and the association between these variables was analyzed by Fisher’s exact test. Survival curves were constructed using the Kaplan–Meier method and compared by log-rank test. All statistical analyses were performed using SPSS statistics package. RESULTS: The mean age of patients in the photosensitive and non-photosensitive groups was 42 years and 67 years, respectively (p<0.0001). A previous history of malignant diseases was more common in the photosensitive group (p=0.001). In both groups, most tumors showed a pathological stage I/II disease. Overall and cancer-specific survival were not statistically different. However, disease-free interval showed a significant difference (p=0.01) between the photosensitive and non-photosensitive patients. CONCLUSIONS: Photosensitive patients presented LLSCC at earlier age but it usually was not the primary tumor in these patients. Furthermore, a more aggressive pathological behavior was not seen when compared with tumors from non-photosensitive patients. The disease-free interval was lower in photosensitive patients, as expected. Key words:Lip cancer, Xeroderma Pigmentosum, Albinism, Lupus erythematosus. |
format | Online Article Text |
id | pubmed-5822543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58225432018-02-26 Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 Borges, Jorena-Fraga-Pimenta Lanaro, Nattália-Di Bernardo, Vagner-Gonçalves Albano, Rodolpho-Mattos Dias, Fernando de Faria, Paulo-Antônio-Silvestre Pinto, Luis-Felipe-Ribeiro Lourenço, Simone-de Queiroz-Chaves Med Oral Patol Oral Cir Bucal Research BACKGROUND: Lower lip squamous cell carcinoma (LLSCC) is a common malignancy of the head and neck, being mainly a consequence of a chronic exposure to ultraviolet (UV) light solar radiation. Here, we evaluated the clinicopathological profile of patients with photosensitive disorders (xeroderma pigmentosum, lupus erythematosus and albinism) that developed LLSCC. MATERIAL AND METHODS: Data from patients who had a diagnosed LLSCC with a prior xeroderma pigmentosum, lupus erythematosus or albinism diagnosis that were treated at INCA from 1999 to 2012 were collected from patients’ medical records (n=16). The control group was composed of 68 patients with LLSCC without a medical history of photosensitivity. The clinicopathological data of this study population were collected and the association between these variables was analyzed by Fisher’s exact test. Survival curves were constructed using the Kaplan–Meier method and compared by log-rank test. All statistical analyses were performed using SPSS statistics package. RESULTS: The mean age of patients in the photosensitive and non-photosensitive groups was 42 years and 67 years, respectively (p<0.0001). A previous history of malignant diseases was more common in the photosensitive group (p=0.001). In both groups, most tumors showed a pathological stage I/II disease. Overall and cancer-specific survival were not statistically different. However, disease-free interval showed a significant difference (p=0.01) between the photosensitive and non-photosensitive patients. CONCLUSIONS: Photosensitive patients presented LLSCC at earlier age but it usually was not the primary tumor in these patients. Furthermore, a more aggressive pathological behavior was not seen when compared with tumors from non-photosensitive patients. The disease-free interval was lower in photosensitive patients, as expected. Key words:Lip cancer, Xeroderma Pigmentosum, Albinism, Lupus erythematosus. Medicina Oral S.L. 2018-01 2017-12-24 /pmc/articles/PMC5822543/ /pubmed/29274161 http://dx.doi.org/10.4317/medoral.21960 Text en Copyright: © 2018 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Borges, Jorena-Fraga-Pimenta Lanaro, Nattália-Di Bernardo, Vagner-Gonçalves Albano, Rodolpho-Mattos Dias, Fernando de Faria, Paulo-Antônio-Silvestre Pinto, Luis-Felipe-Ribeiro Lourenço, Simone-de Queiroz-Chaves Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 |
title | Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 |
title_full | Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 |
title_fullStr | Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 |
title_full_unstemmed | Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 |
title_short | Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 |
title_sort | lower lip squamous cell carcinoma in patients with photosensitive disorders: analysis of cases treated at the brazilian national cancer institute (inca) from 1999 to 2012 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822543/ https://www.ncbi.nlm.nih.gov/pubmed/29274161 http://dx.doi.org/10.4317/medoral.21960 |
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