A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis

Tripterygium wilfordii Hook.f. (TWHF) is a traditional Chinese herb long used for rheumatoid arthritis (RA) treatment, in modern times, often in the form of various Tripterygium wilfordii Hook.f. preparations (TWPs). This systematic review and meta-analysis focuses on analyzing the clinical efficacy...

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Autores principales: Wang, Jing, Chen, Na, Fang, Liang, Feng, Zhe, Li, Guochun, Mucelli, Attilio, Zhang, Xu, Zhou, Xueping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822783/
https://www.ncbi.nlm.nih.gov/pubmed/29576791
http://dx.doi.org/10.1155/2018/1567463
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author Wang, Jing
Chen, Na
Fang, Liang
Feng, Zhe
Li, Guochun
Mucelli, Attilio
Zhang, Xu
Zhou, Xueping
author_facet Wang, Jing
Chen, Na
Fang, Liang
Feng, Zhe
Li, Guochun
Mucelli, Attilio
Zhang, Xu
Zhou, Xueping
author_sort Wang, Jing
collection PubMed
description Tripterygium wilfordii Hook.f. (TWHF) is a traditional Chinese herb long used for rheumatoid arthritis (RA) treatment, in modern times, often in the form of various Tripterygium wilfordii Hook.f. preparations (TWPs). This systematic review and meta-analysis focuses on analyzing the clinical efficacy and safety of TWPs in the treatment of RA. Databases were searched to collect the randomized controlled trials (RCTs) on TWPs treating RA published on or before April 10, 2017. Data from 11 studies were included in this meta-analysis. Compared with the control group, TWPs can increase effectiveness, while decreasing erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), and risk of adverse events. TWPs treatment was also more effective than treatment by conventional western medicine (CWM) and Chinese patent medicine or placebo (COP). TWPs significantly decreased the risk of adverse events compared with the CWM group, but not compared with the COP group. Current evidence shows that TWPs are more effective than other western or Chinese medicines we included in this meta-analysis for RA treatment with relatively lower toxicity.
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spelling pubmed-58227832018-03-25 A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis Wang, Jing Chen, Na Fang, Liang Feng, Zhe Li, Guochun Mucelli, Attilio Zhang, Xu Zhou, Xueping Evid Based Complement Alternat Med Review Article Tripterygium wilfordii Hook.f. (TWHF) is a traditional Chinese herb long used for rheumatoid arthritis (RA) treatment, in modern times, often in the form of various Tripterygium wilfordii Hook.f. preparations (TWPs). This systematic review and meta-analysis focuses on analyzing the clinical efficacy and safety of TWPs in the treatment of RA. Databases were searched to collect the randomized controlled trials (RCTs) on TWPs treating RA published on or before April 10, 2017. Data from 11 studies were included in this meta-analysis. Compared with the control group, TWPs can increase effectiveness, while decreasing erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), and risk of adverse events. TWPs treatment was also more effective than treatment by conventional western medicine (CWM) and Chinese patent medicine or placebo (COP). TWPs significantly decreased the risk of adverse events compared with the CWM group, but not compared with the COP group. Current evidence shows that TWPs are more effective than other western or Chinese medicines we included in this meta-analysis for RA treatment with relatively lower toxicity. Hindawi 2018-02-08 /pmc/articles/PMC5822783/ /pubmed/29576791 http://dx.doi.org/10.1155/2018/1567463 Text en Copyright © 2018 Jing Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Jing
Chen, Na
Fang, Liang
Feng, Zhe
Li, Guochun
Mucelli, Attilio
Zhang, Xu
Zhou, Xueping
A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis
title A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis
title_full A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis
title_fullStr A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis
title_full_unstemmed A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis
title_short A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis
title_sort systematic review about the efficacy and safety of tripterygium wilfordii hook.f. preparations used for the management of rheumatoid arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822783/
https://www.ncbi.nlm.nih.gov/pubmed/29576791
http://dx.doi.org/10.1155/2018/1567463
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