Accelerated Blood Clearance (ABC) Phenomenon Favors the Accumulation of Tartar Emetic in Pegylated Liposomes in BALB/c Mice Liver

Tartar emetic (TE) was the first drug used to treat leishmaniasis. However, its use was discontinued due to high toxicity. Association of TE with liposomes is a strategy to reduce its side effects. Pegylated liposomes (Lpeg) present lower rates of uptake by macrophages and prolonged circulation comp...

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Detalles Bibliográficos
Autores principales: Lopes, Tamara C. M., Silva, Débora F., Costa, Walyson C., Frézard, Frédéric, Barichello, José M., Silva-Barcellos, Neila M., de Lima, Wanderson G., Rezende, Simone A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822796/
https://www.ncbi.nlm.nih.gov/pubmed/29593857
http://dx.doi.org/10.1155/2018/9076723

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