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Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects

We examined the effects of essential oil from legal (THC <0.2% w/v) hemp variety on the nervous system in 5 healthy volunteers. GC/EIMS and GC/FID analysis of the EO showed that the main components were myrcene and β-caryophyllene. The experiment consisted of measuring autonomic nervous system (A...

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Autores principales: Gulluni, Nadia, Re, Tania, Loiacono, Idalba, Lanzo, Giovanni, Gori, Luigi, Macchi, Claudio, Epifani, Francesco, Bragazzi, Nicola, Firenzuoli, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822802/
https://www.ncbi.nlm.nih.gov/pubmed/29576792
http://dx.doi.org/10.1155/2018/1709182
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author Gulluni, Nadia
Re, Tania
Loiacono, Idalba
Lanzo, Giovanni
Gori, Luigi
Macchi, Claudio
Epifani, Francesco
Bragazzi, Nicola
Firenzuoli, Fabio
author_facet Gulluni, Nadia
Re, Tania
Loiacono, Idalba
Lanzo, Giovanni
Gori, Luigi
Macchi, Claudio
Epifani, Francesco
Bragazzi, Nicola
Firenzuoli, Fabio
author_sort Gulluni, Nadia
collection PubMed
description We examined the effects of essential oil from legal (THC <0.2% w/v) hemp variety on the nervous system in 5 healthy volunteers. GC/EIMS and GC/FID analysis of the EO showed that the main components were myrcene and β-caryophyllene. The experiment consisted of measuring autonomic nervous system (ANS) parameters; evaluations of the mood state; and electroencephalography (EEG) recording before treatment, during treatment, and after hemp inhalation periods as compared with control conditions. The results revealed decreased diastolic blood pressure, increased heart rate, and significant increased skin temperature. The subjects described themselves as more energetic, relaxed, and calm. The analysis EEG showed a significant increase in the mean frequency of alpha (8–13 Hz) and significant decreased mean frequency and relative power of beta 2 (18,5–30 Hz) waves. Moreover, an increased power, relative power, and amplitude of theta (4–8 Hz) and alpha brain waves activities and an increment in the delta wave (0,5–4 Hz) power and relative power was recorded in the posterior region of the brain. These results suggest that the brain wave activity and ANS are affected by the inhalation of the EO of Cannabis sativa suggesting a neuromodular activity in cases of stress, depression, and anxiety.
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spelling pubmed-58228022018-03-25 Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects Gulluni, Nadia Re, Tania Loiacono, Idalba Lanzo, Giovanni Gori, Luigi Macchi, Claudio Epifani, Francesco Bragazzi, Nicola Firenzuoli, Fabio Evid Based Complement Alternat Med Research Article We examined the effects of essential oil from legal (THC <0.2% w/v) hemp variety on the nervous system in 5 healthy volunteers. GC/EIMS and GC/FID analysis of the EO showed that the main components were myrcene and β-caryophyllene. The experiment consisted of measuring autonomic nervous system (ANS) parameters; evaluations of the mood state; and electroencephalography (EEG) recording before treatment, during treatment, and after hemp inhalation periods as compared with control conditions. The results revealed decreased diastolic blood pressure, increased heart rate, and significant increased skin temperature. The subjects described themselves as more energetic, relaxed, and calm. The analysis EEG showed a significant increase in the mean frequency of alpha (8–13 Hz) and significant decreased mean frequency and relative power of beta 2 (18,5–30 Hz) waves. Moreover, an increased power, relative power, and amplitude of theta (4–8 Hz) and alpha brain waves activities and an increment in the delta wave (0,5–4 Hz) power and relative power was recorded in the posterior region of the brain. These results suggest that the brain wave activity and ANS are affected by the inhalation of the EO of Cannabis sativa suggesting a neuromodular activity in cases of stress, depression, and anxiety. Hindawi 2018-01-17 /pmc/articles/PMC5822802/ /pubmed/29576792 http://dx.doi.org/10.1155/2018/1709182 Text en Copyright © 2018 Nadia Gulluni et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gulluni, Nadia
Re, Tania
Loiacono, Idalba
Lanzo, Giovanni
Gori, Luigi
Macchi, Claudio
Epifani, Francesco
Bragazzi, Nicola
Firenzuoli, Fabio
Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
title Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
title_full Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
title_fullStr Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
title_full_unstemmed Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
title_short Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
title_sort cannabis essential oil: a preliminary study for the evaluation of the brain effects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822802/
https://www.ncbi.nlm.nih.gov/pubmed/29576792
http://dx.doi.org/10.1155/2018/1709182
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