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Advances of stem cell based-therapeutic approaches for tendon repair
Tendon injuries are significant clinical problems. Current treatments often result in incomplete repair or healing, which may lead to reduced function and rupture. Stem cell-based therapy is a promising intervention for tendon repair. In this article, we attempt to provide a brief overview on the re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Speaking Orthopaedic Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822968/ https://www.ncbi.nlm.nih.gov/pubmed/29662801 http://dx.doi.org/10.1016/j.jot.2017.03.007 |
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author | Liu, Lidi Hindieh, Jennifer Leong, Daniel J. Sun, Hui B. |
author_facet | Liu, Lidi Hindieh, Jennifer Leong, Daniel J. Sun, Hui B. |
author_sort | Liu, Lidi |
collection | PubMed |
description | Tendon injuries are significant clinical problems. Current treatments often result in incomplete repair or healing, which may lead to reduced function and rupture. Stem cell-based therapy is a promising intervention for tendon repair. In this article, we attempt to provide a brief overview on the recent progress in the field, current understanding of the underlying mechanisms of the approach, and the potential of stem cell-based therapies beyond cell implantation. We conclude the review by sharing our viewpoints on the challenges, opportunities, and future directions of this approach. The translational potential of this article: This paper reviews recent progress on stem cell-based therapeutic approaches for tendon repair, which highlights its translational potential and challenges. |
format | Online Article Text |
id | pubmed-5822968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Chinese Speaking Orthopaedic Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-58229682018-04-16 Advances of stem cell based-therapeutic approaches for tendon repair Liu, Lidi Hindieh, Jennifer Leong, Daniel J. Sun, Hui B. J Orthop Translat Review Article Tendon injuries are significant clinical problems. Current treatments often result in incomplete repair or healing, which may lead to reduced function and rupture. Stem cell-based therapy is a promising intervention for tendon repair. In this article, we attempt to provide a brief overview on the recent progress in the field, current understanding of the underlying mechanisms of the approach, and the potential of stem cell-based therapies beyond cell implantation. We conclude the review by sharing our viewpoints on the challenges, opportunities, and future directions of this approach. The translational potential of this article: This paper reviews recent progress on stem cell-based therapeutic approaches for tendon repair, which highlights its translational potential and challenges. Chinese Speaking Orthopaedic Society 2017-04-13 /pmc/articles/PMC5822968/ /pubmed/29662801 http://dx.doi.org/10.1016/j.jot.2017.03.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Liu, Lidi Hindieh, Jennifer Leong, Daniel J. Sun, Hui B. Advances of stem cell based-therapeutic approaches for tendon repair |
title | Advances of stem cell based-therapeutic approaches for tendon repair |
title_full | Advances of stem cell based-therapeutic approaches for tendon repair |
title_fullStr | Advances of stem cell based-therapeutic approaches for tendon repair |
title_full_unstemmed | Advances of stem cell based-therapeutic approaches for tendon repair |
title_short | Advances of stem cell based-therapeutic approaches for tendon repair |
title_sort | advances of stem cell based-therapeutic approaches for tendon repair |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822968/ https://www.ncbi.nlm.nih.gov/pubmed/29662801 http://dx.doi.org/10.1016/j.jot.2017.03.007 |
work_keys_str_mv | AT liulidi advancesofstemcellbasedtherapeuticapproachesfortendonrepair AT hindiehjennifer advancesofstemcellbasedtherapeuticapproachesfortendonrepair AT leongdanielj advancesofstemcellbasedtherapeuticapproachesfortendonrepair AT sunhuib advancesofstemcellbasedtherapeuticapproachesfortendonrepair |