Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing

We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reduc...

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Detalles Bibliográficos
Autores principales: Trapani, Laura, Pallottini, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2009
Materias:
Mini-Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823086/
https://www.ncbi.nlm.nih.gov/pubmed/19578714
http://dx.doi.org/10.1100/tsw.2009.81
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author Trapani, Laura
Pallottini, Valentina
author_facet Trapani, Laura
Pallottini, Valentina
author_sort Trapani, Laura
collection PubMed
description We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) during adult life and during aging, have been described. In addition some pharmacological interventions to control proper HMGR regulation and, in turn, cholesterol homeostasis maintenance will be introduced.
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spelling pubmed-58230862018-03-14 Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing Trapani, Laura Pallottini, Valentina ScientificWorldJournal Mini-Review Article We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) during adult life and during aging, have been described. In addition some pharmacological interventions to control proper HMGR regulation and, in turn, cholesterol homeostasis maintenance will be introduced. TheScientificWorldJOURNAL 2009-07-04 /pmc/articles/PMC5823086/ /pubmed/19578714 http://dx.doi.org/10.1100/tsw.2009.81 Text en Copyright © 2009 Laura Trapani and Valentina Pallottini. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Trapani, Laura
Pallottini, Valentina
Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing
title Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing
title_full Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing
title_fullStr Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing
title_full_unstemmed Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing
title_short Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing
title_sort hypercholesterolemia and 3-hydroxy 3-methylglutaryl coenzyme a reductase regulation during ageing
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823086/
https://www.ncbi.nlm.nih.gov/pubmed/19578714
http://dx.doi.org/10.1100/tsw.2009.81
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