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Statins in Neurological Disorders: Mechanisms and Therapeutic Value
Statins are well-tolerated, mainstay drugs in cardiovascular risk management. In addition to their cholesterol-lowering properties, statins also have anti-inflammatory, vasculoprotective, and antioxidant effects. They have also been associated in some epidemiologic studies with reduced risk of Alzhe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823201/ https://www.ncbi.nlm.nih.gov/pubmed/19882094 http://dx.doi.org/10.1100/tsw.2009.141 |
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author | Reiss, Allison B. Wirkowski, Elzbieta |
author_facet | Reiss, Allison B. Wirkowski, Elzbieta |
author_sort | Reiss, Allison B. |
collection | PubMed |
description | Statins are well-tolerated, mainstay drugs in cardiovascular risk management. In addition to their cholesterol-lowering properties, statins also have anti-inflammatory, vasculoprotective, and antioxidant effects. They have also been associated in some epidemiologic studies with reduced risk of Alzheimer's disease (AD), and a link between cholesterol and late-onset AD has been documented. Experimental studies in cell culture systems and animal models show that statins have neuroprotective effects that may ameliorate the damage inflicted by stroke and AD. Human studies have garnered compelling evidence that treatment with statins reduces ischemic stroke incidence independent of their lipid-lowering effects. There is also the possibility that statins and extremely low cholesterol levels may increase the risk of intracranial hemorrhage. In this review, we discuss the potential reasons for the effect of statins on stroke and AD, and the multiple mechanisms of action of this class of lipid-lowering drugs. |
format | Online Article Text |
id | pubmed-5823201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-58232012018-03-14 Statins in Neurological Disorders: Mechanisms and Therapeutic Value Reiss, Allison B. Wirkowski, Elzbieta ScientificWorldJournal Review Article Statins are well-tolerated, mainstay drugs in cardiovascular risk management. In addition to their cholesterol-lowering properties, statins also have anti-inflammatory, vasculoprotective, and antioxidant effects. They have also been associated in some epidemiologic studies with reduced risk of Alzheimer's disease (AD), and a link between cholesterol and late-onset AD has been documented. Experimental studies in cell culture systems and animal models show that statins have neuroprotective effects that may ameliorate the damage inflicted by stroke and AD. Human studies have garnered compelling evidence that treatment with statins reduces ischemic stroke incidence independent of their lipid-lowering effects. There is also the possibility that statins and extremely low cholesterol levels may increase the risk of intracranial hemorrhage. In this review, we discuss the potential reasons for the effect of statins on stroke and AD, and the multiple mechanisms of action of this class of lipid-lowering drugs. TheScientificWorldJOURNAL 2009-11-01 /pmc/articles/PMC5823201/ /pubmed/19882094 http://dx.doi.org/10.1100/tsw.2009.141 Text en Copyright © 2009 Allison B Reiss and Elzbieta Wirkowski. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Reiss, Allison B. Wirkowski, Elzbieta Statins in Neurological Disorders: Mechanisms and Therapeutic Value |
title | Statins in Neurological Disorders: Mechanisms and Therapeutic Value |
title_full | Statins in Neurological Disorders: Mechanisms and Therapeutic Value |
title_fullStr | Statins in Neurological Disorders: Mechanisms and Therapeutic Value |
title_full_unstemmed | Statins in Neurological Disorders: Mechanisms and Therapeutic Value |
title_short | Statins in Neurological Disorders: Mechanisms and Therapeutic Value |
title_sort | statins in neurological disorders: mechanisms and therapeutic value |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823201/ https://www.ncbi.nlm.nih.gov/pubmed/19882094 http://dx.doi.org/10.1100/tsw.2009.141 |
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