Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia

Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance...

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Detalles Bibliográficos
Autores principales: Chernyaeva, Ekaterina, Rotkevich, Mikhail, Krasheninnikova, Ksenia, Yurchenko, Andrey, Vyazovaya, Anna, Mokrousov, Igor, Solovieva, Natalia, Zhuravlev, Viacheslav, Yablonsky, Piotr, O’Brien, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823328/
https://www.ncbi.nlm.nih.gov/pubmed/29460750
http://dx.doi.org/10.3201/eid2403.170151
Descripción
Sumario:Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance mutations. We identify known and novel genome determinants related to bacterial virulence, pathogenicity, and drug resistance.

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