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A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease
Arterial pressure waves have been described in one dimension using several approaches, such as lumped (Windkessel) or distributed (using Navier-Stokes equations) models. An alternative approach consists of modeling blood pressure waves using a Korteweg-de Vries (KdV) equation and representing pressu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823431/ https://www.ncbi.nlm.nih.gov/pubmed/29599937 http://dx.doi.org/10.1155/2018/1364185 |
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author | Alfonso, Manuel R. Armentano, Ricardo L. Cymberknop, Leandro J. Ghigo, Arthur R. Pessana, Franco M. Legnani, Walter E. |
author_facet | Alfonso, Manuel R. Armentano, Ricardo L. Cymberknop, Leandro J. Ghigo, Arthur R. Pessana, Franco M. Legnani, Walter E. |
author_sort | Alfonso, Manuel R. |
collection | PubMed |
description | Arterial pressure waves have been described in one dimension using several approaches, such as lumped (Windkessel) or distributed (using Navier-Stokes equations) models. An alternative approach consists of modeling blood pressure waves using a Korteweg-de Vries (KdV) equation and representing pressure waves as combinations of solitons. This model captures many key features of wave propagation in the systemic network and, in particular, pulse pressure amplification (PPA), which is a mechanical biomarker of cardiovascular risk. The main objective of this work is to compare the propagation dynamics described by a KdV equation in a human-like arterial tree using acquired pressure waves. Furthermore, we analyzed the ability of our model to reproduce induced elastic changes in PPA due to different pathological conditions. To this end, numerical simulations were performed using acquired central pressure signals from different subject groups (young, adults, and hypertensive) as input and then comparing the output of the model with measured radial artery pressure waveforms. Pathological conditions were modeled as changes in arterial elasticity (E). Numerical results showed that the model was able to propagate acquired pressure waveforms and to reproduce PPA variations as a consequence of elastic changes. Calculated elasticity for each group was in accordance with the existing literature. |
format | Online Article Text |
id | pubmed-5823431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58234312018-03-29 A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease Alfonso, Manuel R. Armentano, Ricardo L. Cymberknop, Leandro J. Ghigo, Arthur R. Pessana, Franco M. Legnani, Walter E. J Healthc Eng Research Article Arterial pressure waves have been described in one dimension using several approaches, such as lumped (Windkessel) or distributed (using Navier-Stokes equations) models. An alternative approach consists of modeling blood pressure waves using a Korteweg-de Vries (KdV) equation and representing pressure waves as combinations of solitons. This model captures many key features of wave propagation in the systemic network and, in particular, pulse pressure amplification (PPA), which is a mechanical biomarker of cardiovascular risk. The main objective of this work is to compare the propagation dynamics described by a KdV equation in a human-like arterial tree using acquired pressure waves. Furthermore, we analyzed the ability of our model to reproduce induced elastic changes in PPA due to different pathological conditions. To this end, numerical simulations were performed using acquired central pressure signals from different subject groups (young, adults, and hypertensive) as input and then comparing the output of the model with measured radial artery pressure waveforms. Pathological conditions were modeled as changes in arterial elasticity (E). Numerical results showed that the model was able to propagate acquired pressure waveforms and to reproduce PPA variations as a consequence of elastic changes. Calculated elasticity for each group was in accordance with the existing literature. Hindawi 2018-01-16 /pmc/articles/PMC5823431/ /pubmed/29599937 http://dx.doi.org/10.1155/2018/1364185 Text en Copyright © 2018 Manuel R. Alfonso et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Alfonso, Manuel R. Armentano, Ricardo L. Cymberknop, Leandro J. Ghigo, Arthur R. Pessana, Franco M. Legnani, Walter E. A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease |
title | A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease |
title_full | A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease |
title_fullStr | A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease |
title_full_unstemmed | A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease |
title_short | A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease |
title_sort | novel interpretation for arterial pulse pressure amplification in health and disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823431/ https://www.ncbi.nlm.nih.gov/pubmed/29599937 http://dx.doi.org/10.1155/2018/1364185 |
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