Cargando…

Therapeutic potential of berberine against neurodegenerative diseases

Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 dia...

Descripción completa

Detalles Bibliográficos
Autores principales: JIANG, WenXiao, LI, ShiHua, LI, XiaoJiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823536/
https://www.ncbi.nlm.nih.gov/pubmed/25749423
http://dx.doi.org/10.1007/s11427-015-4829-0
_version_ 1783301894876168192
author JIANG, WenXiao
LI, ShiHua
LI, XiaoJiang
author_facet JIANG, WenXiao
LI, ShiHua
LI, XiaoJiang
author_sort JIANG, WenXiao
collection PubMed
description Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR’s effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer’s disease (AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson’s disease (PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.
format Online
Article
Text
id pubmed-5823536
institution National Center for Biotechnology Information
language English
publishDate 2015
record_format MEDLINE/PubMed
spelling pubmed-58235362018-02-22 Therapeutic potential of berberine against neurodegenerative diseases JIANG, WenXiao LI, ShiHua LI, XiaoJiang Sci China Life Sci Article Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR’s effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer’s disease (AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson’s disease (PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases. 2015-03-06 2015-06 /pmc/articles/PMC5823536/ /pubmed/25749423 http://dx.doi.org/10.1007/s11427-015-4829-0 Text en http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
JIANG, WenXiao
LI, ShiHua
LI, XiaoJiang
Therapeutic potential of berberine against neurodegenerative diseases
title Therapeutic potential of berberine against neurodegenerative diseases
title_full Therapeutic potential of berberine against neurodegenerative diseases
title_fullStr Therapeutic potential of berberine against neurodegenerative diseases
title_full_unstemmed Therapeutic potential of berberine against neurodegenerative diseases
title_short Therapeutic potential of berberine against neurodegenerative diseases
title_sort therapeutic potential of berberine against neurodegenerative diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823536/
https://www.ncbi.nlm.nih.gov/pubmed/25749423
http://dx.doi.org/10.1007/s11427-015-4829-0
work_keys_str_mv AT jiangwenxiao therapeuticpotentialofberberineagainstneurodegenerativediseases
AT lishihua therapeuticpotentialofberberineagainstneurodegenerativediseases
AT lixiaojiang therapeuticpotentialofberberineagainstneurodegenerativediseases