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Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer
Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-metastasis classification, predicting disease recurrence and prognosis in patients undergoing gastrectomy is clinically difficult. We investigated the depth of tumor invasion and tumor siz...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823562/ https://www.ncbi.nlm.nih.gov/pubmed/29492212 http://dx.doi.org/10.18632/oncotarget.23953 |
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author | Haraguchi, Naoto Arigami, Takaaki Uenosono, Yoshikazu Yanagita, Shigehiro Uchikado, Yasuto Mori, Shinichiro Kurahara, Hiroshi Kijima, Yuko Nakajo, Akihiro Maemura, Kosei Ishigami, Sumiya Natsugoe, Shoji |
author_facet | Haraguchi, Naoto Arigami, Takaaki Uenosono, Yoshikazu Yanagita, Shigehiro Uchikado, Yasuto Mori, Shinichiro Kurahara, Hiroshi Kijima, Yuko Nakajo, Akihiro Maemura, Kosei Ishigami, Sumiya Natsugoe, Shoji |
author_sort | Haraguchi, Naoto |
collection | PubMed |
description | Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-metastasis classification, predicting disease recurrence and prognosis in patients undergoing gastrectomy is clinically difficult. We investigated the depth of tumor invasion and tumor size in resected specimens from patients with gastric cancer and assessed the clinical utility of primary tumor score (PTS) calculated by tumor depth and size as a prognostic marker. We classified 247 patients with gastric cancer into three groups based on cut-off values for deeper tumor invasion (pT2–T4) and larger tumor size (≥ 45 mm) as a PTS of 2 (both abnormalities), 1 (one abnormality), or 0 (neither abnormality). PTS correlated significantly with lymph node metastasis, lymphovascular invasion, and stage (P < 0.0001 each). Survival differences among groups based on PTS were significant (P < 0.0001). Multivariate analysis identified PTS alone as an independent prognostic factor (P = 0.0363). PTS derived from primary tumor information alone is a potentially useful marker for predicting tumor progression and prognosis in postoperative patients with gastric cancer. |
format | Online Article Text |
id | pubmed-5823562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-58235622018-02-28 Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer Haraguchi, Naoto Arigami, Takaaki Uenosono, Yoshikazu Yanagita, Shigehiro Uchikado, Yasuto Mori, Shinichiro Kurahara, Hiroshi Kijima, Yuko Nakajo, Akihiro Maemura, Kosei Ishigami, Sumiya Natsugoe, Shoji Oncotarget Research Paper Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-metastasis classification, predicting disease recurrence and prognosis in patients undergoing gastrectomy is clinically difficult. We investigated the depth of tumor invasion and tumor size in resected specimens from patients with gastric cancer and assessed the clinical utility of primary tumor score (PTS) calculated by tumor depth and size as a prognostic marker. We classified 247 patients with gastric cancer into three groups based on cut-off values for deeper tumor invasion (pT2–T4) and larger tumor size (≥ 45 mm) as a PTS of 2 (both abnormalities), 1 (one abnormality), or 0 (neither abnormality). PTS correlated significantly with lymph node metastasis, lymphovascular invasion, and stage (P < 0.0001 each). Survival differences among groups based on PTS were significant (P < 0.0001). Multivariate analysis identified PTS alone as an independent prognostic factor (P = 0.0363). PTS derived from primary tumor information alone is a potentially useful marker for predicting tumor progression and prognosis in postoperative patients with gastric cancer. Impact Journals LLC 2018-01-04 /pmc/articles/PMC5823562/ /pubmed/29492212 http://dx.doi.org/10.18632/oncotarget.23953 Text en Copyright: © 2018 Haraguchi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Haraguchi, Naoto Arigami, Takaaki Uenosono, Yoshikazu Yanagita, Shigehiro Uchikado, Yasuto Mori, Shinichiro Kurahara, Hiroshi Kijima, Yuko Nakajo, Akihiro Maemura, Kosei Ishigami, Sumiya Natsugoe, Shoji Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer |
title | Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer |
title_full | Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer |
title_fullStr | Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer |
title_full_unstemmed | Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer |
title_short | Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer |
title_sort | clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823562/ https://www.ncbi.nlm.nih.gov/pubmed/29492212 http://dx.doi.org/10.18632/oncotarget.23953 |
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