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Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

Overexpression of protein tyrosine phosphatase PTP4A oncoproteins is common in many human cancers and is associated with poor patient prognosis and survival. We observed elevated levels of PTP4A3 phosphatase in 79% of human ovarian tumor samples, with significant overexpression in tumor endothelium...

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Detalles Bibliográficos
Autores principales:	McQueeney, Kelley E., Salamoun, Joseph M., Burnett, James C., Barabutis, Nektarios, Pekic, Paula, Lewandowski, Sophie L., Llaneza, Danielle C., Cornelison, Robert, Bai, Yunpeng, Zhang, Zhong-Yin, Catravas, John D., Landen, Charles N., Wipf, Peter, Lazo, John S., Sharlow, Elizabeth R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823565/ https://www.ncbi.nlm.nih.gov/pubmed/29492190 http://dx.doi.org/10.18632/oncotarget.23787

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