Cargando…

Octogenarians with EGFR-mutated non-small cell lung cancer treated by tyrosine-kinase inhibitor: a multicentric real-world study assessing tolerance and efficacy (OCTOMUT study)

OBJECTIVE: To assess efficacy and tolerance of EGFR tyrosine-kinase inhibitors (TKIs) for advanced EGFR-mutated non-small cell lung cancer (NSCLC) in octogenarians. PATIENTS AND METHODS: Patients aged 80 years or older with EGFR-mutated NSCLC treated by EGFR TKI between January 2011 and March 2015 w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corre, Romain, Gervais, Radj, Guisier, Florian, Tassy, Louis, Vinas, Florent, Lamy, Régine, Fraboulet, Gislaine, Greillier, Laurent, Doubre, Helene, Descourt, Renaud, Chouaid, Christos, Auliac, Jean-Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823568/ https://www.ncbi.nlm.nih.gov/pubmed/29492192 http://dx.doi.org/10.18632/oncotarget.23836

Ejemplares similares

Efficacy and safety of programmed cell-death-protein-1 and its ligand inhibitors in pretreated patients with epidermal growth-factor receptor-mutated or anaplastic lymphoma kinase-translocated lung adenocarcinoma
por: Bylicki, Olivier, et al.
Publicado: (2020)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival
por: Rajala, Ammaji, et al.
Publicado: (2016)

Impact of Programmed Death Ligand 1 Expression in Advanced Non-Small–Cell Lung Cancer Patients, Treated by Chemotherapy (GFPC 06-2015 Study)
por: Auliac, Jean-Bernard, et al.
Publicado: (2020)

Phase III randomized study of carboplatin pemetrexed with or without bevacizumab with initial versus “at progression” cerebral radiotherapy in advanced non squamous non-small cell lung cancer with asymptomatic brain metastasis
por: Monnet, Isabelle, et al.
Publicado: (2021)

Non-Small Cell Lung Cancer Patients Harboring HER2 Mutations: Clinical Characteristics and Management in a Real-Life Setting. Cohort HER2 EXPLORE GFPC 02–14
por: Auliac, Jean-Bernard, et al.
Publicado: (2019)

PD-L1-expression patterns in large-cell neuroendocrine carcinoma of the lung: potential implications for use of immunotherapy in these patients: the GFPC 03-2017 “EPNEC” study
por: Arpin, Dominique, et al.
Publicado: (2020)

Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells
por: Løhr, Mille, et al.
Publicado: (2014)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain
por: Chang, Jean-Yun, et al.
Publicado: (2015)

Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent
por: Sabbieti, Maria Giovanna, et al.
Publicado: (2015)

Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival
por: Kim, Sangkyu, et al.
Publicado: (2015)

The function of cux1 in oxidative dna damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
por: Ramdzan, Zubaidah M., et al.
Publicado: (2015)

DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3ʹ-end GC density
por: Yu, Bo, et al.
Publicado: (2015)

Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
por: Tsuchihashi, Nana Akagi, et al.
Publicado: (2014)

Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium
por: Santos, Júlia, et al.
Publicado: (2014)

Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors
por: Corsini, Emanuela, et al.
Publicado: (2015)

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
por: Yousef, Hanadie, et al.
Publicado: (2015)

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies
por: Burks, Tyesha N., et al.
Publicado: (2015)

EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells
por: Lee, Ju-Hee, et al.
Publicado: (2015)

Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats
por: Lesovaya, Ekaterina A., et al.
Publicado: (2015)

New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor
por: Kanashiro-Takeuchi, Rosemeire M., et al.
Publicado: (2015)

PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes
por: Chen, Yng-Tay, et al.
Publicado: (2015)

MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts
por: Liao, Po-Hsiang, et al.
Publicado: (2015)

Association between serum uric acid and bone health in general population: a large and multicentre study
por: Lin, Xianfeng, et al.
Publicado: (2015)

c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells
por: Chen, Pei-Min, et al.
Publicado: (2015)

Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development
por: Beheshti, Afshin, et al.
Publicado: (2015)

RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium
por: Park, Sung Wook, et al.
Publicado: (2015)

Rapamycin preserves gut homeostasis during Drosophila aging
por: Fan, Xiaolan, et al.
Publicado: (2015)

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)
por: Bester, Janette, et al.
Publicado: (2015)

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis
por: Lin, Cong, et al.
Publicado: (2015)

IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity
por: Papaconstantinou, John, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ja9tv3s7l3eb2ubuu2k4t47tb1