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Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis
Previous studies have reported inconsistent results regarding the association between homocysteine (Hcy) levels and calcific aortic valve disease (CAVD). We investigate the association between Hcy levels in patients with CAVD and controls by conducting a systematic review and meta-analysis. We condu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823577/ https://www.ncbi.nlm.nih.gov/pubmed/29492225 http://dx.doi.org/10.18632/oncotarget.23938 |
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author | Wu, Guandi Xian, Jiayi Yang, Xi Li, Jiaying Liu, Jichen Dong, Wenhui Su, Shuwen Li, Jun Tu, Yan Peng, Jian Xu, Dingli Zeng, Qingchun |
author_facet | Wu, Guandi Xian, Jiayi Yang, Xi Li, Jiaying Liu, Jichen Dong, Wenhui Su, Shuwen Li, Jun Tu, Yan Peng, Jian Xu, Dingli Zeng, Qingchun |
author_sort | Wu, Guandi |
collection | PubMed |
description | Previous studies have reported inconsistent results regarding the association between homocysteine (Hcy) levels and calcific aortic valve disease (CAVD). We investigate the association between Hcy levels in patients with CAVD and controls by conducting a systematic review and meta-analysis. We conducted a systematic search of studies published prior to the end of March 2017 in the PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and the Chinese Biomedical Literature databases. Eligible studies evaluating plasma Hcy levels in CAVD patients and controls were identified by two independent investigators. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were estimated using the random-effects model. Ten studies involving 6349 participants were included. Pooled analysis demonstrated that Hcy levels were significantly elevated in patients with CAVD compared with controls (pooled SMD: 0.57, 95% CI: 0.36–0.79). This elevation was more obvious in American and Asian populations than in Turkish populations. Furthermore, Hcy levels were significantly elevated in patients with mild-to-moderate CAVD and severe CAVD. Our results demonstrate that CAVD is associated with elevated Hcy levels. |
format | Online Article Text |
id | pubmed-5823577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-58235772018-02-28 Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis Wu, Guandi Xian, Jiayi Yang, Xi Li, Jiaying Liu, Jichen Dong, Wenhui Su, Shuwen Li, Jun Tu, Yan Peng, Jian Xu, Dingli Zeng, Qingchun Oncotarget Meta-Analysis Previous studies have reported inconsistent results regarding the association between homocysteine (Hcy) levels and calcific aortic valve disease (CAVD). We investigate the association between Hcy levels in patients with CAVD and controls by conducting a systematic review and meta-analysis. We conducted a systematic search of studies published prior to the end of March 2017 in the PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and the Chinese Biomedical Literature databases. Eligible studies evaluating plasma Hcy levels in CAVD patients and controls were identified by two independent investigators. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were estimated using the random-effects model. Ten studies involving 6349 participants were included. Pooled analysis demonstrated that Hcy levels were significantly elevated in patients with CAVD compared with controls (pooled SMD: 0.57, 95% CI: 0.36–0.79). This elevation was more obvious in American and Asian populations than in Turkish populations. Furthermore, Hcy levels were significantly elevated in patients with mild-to-moderate CAVD and severe CAVD. Our results demonstrate that CAVD is associated with elevated Hcy levels. Impact Journals LLC 2018-01-03 /pmc/articles/PMC5823577/ /pubmed/29492225 http://dx.doi.org/10.18632/oncotarget.23938 Text en Copyright: © 2018 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Meta-Analysis Wu, Guandi Xian, Jiayi Yang, Xi Li, Jiaying Liu, Jichen Dong, Wenhui Su, Shuwen Li, Jun Tu, Yan Peng, Jian Xu, Dingli Zeng, Qingchun Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis |
title | Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis |
title_full | Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis |
title_fullStr | Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis |
title_full_unstemmed | Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis |
title_short | Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis |
title_sort | association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823577/ https://www.ncbi.nlm.nih.gov/pubmed/29492225 http://dx.doi.org/10.18632/oncotarget.23938 |
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