TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation

Alternative TrkAIII splicing characterises advanced stage metastatic disease and post-therapeutic relapse in neuroblastoma (NB), and in NB models TrkAIII exhibits oncogenic activity. In this study, we report a novel role for TrkAIII in signaling ER stress to the mitochondria in SH-SY5Y NB cells that...

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Detalles Bibliográficos
Autores principales: Farina, Antonietta Rosella, Cappabianca, Lucia, Gneo, Luciana, Ruggeri, Pierdomenico, Mackay, Andrew Reay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823587/
https://www.ncbi.nlm.nih.gov/pubmed/29492201
http://dx.doi.org/10.18632/oncotarget.23618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823587/
https://www.ncbi.nlm.nih.gov/pubmed/29492201
http://dx.doi.org/10.18632/oncotarget.23618

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