Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis

Impaired angiogenesis contributes to delayed wound healing in aging. Hyaluronan (HA) has a close relationship with angiogenesis and wound healing. However, HA content decreases with age. In this study, we used high molecular weight HA (HMW-HA) (1650 kDa), and investigated its effects on wound healin...

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Detalles Bibliográficos
Autores principales: Huang, Luying, Wang, Yi, Liu, Hua, Huang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823590/
https://www.ncbi.nlm.nih.gov/pubmed/29492191
http://dx.doi.org/10.18632/oncotarget.23246
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author Huang, Luying
Wang, Yi
Liu, Hua
Huang, Jianhua
author_facet Huang, Luying
Wang, Yi
Liu, Hua
Huang, Jianhua
author_sort Huang, Luying
collection PubMed
description Impaired angiogenesis contributes to delayed wound healing in aging. Hyaluronan (HA) has a close relationship with angiogenesis and wound healing. However, HA content decreases with age. In this study, we used high molecular weight HA (HMW-HA) (1650 kDa), and investigated its effects on wound healing in old rats by local injection. We found that HMW-HA significantly increases proliferation, migration and tube formation in endothelial cells, and protects endothelial cells against apoptosis. Local injection of HMW-HA promotes wound healing by increasing angiogenesis in old rats. HMW-HA increases the phosphorylation of Src, ERK and AKT, leading to increased angiogenesis, suggesting that local injection of HMW-HA promotes wound healing in elderly patients.
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spelling pubmed-58235902018-02-28 Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis Huang, Luying Wang, Yi Liu, Hua Huang, Jianhua Oncotarget Research Paper: Gerotarget (Focus on Aging) Impaired angiogenesis contributes to delayed wound healing in aging. Hyaluronan (HA) has a close relationship with angiogenesis and wound healing. However, HA content decreases with age. In this study, we used high molecular weight HA (HMW-HA) (1650 kDa), and investigated its effects on wound healing in old rats by local injection. We found that HMW-HA significantly increases proliferation, migration and tube formation in endothelial cells, and protects endothelial cells against apoptosis. Local injection of HMW-HA promotes wound healing by increasing angiogenesis in old rats. HMW-HA increases the phosphorylation of Src, ERK and AKT, leading to increased angiogenesis, suggesting that local injection of HMW-HA promotes wound healing in elderly patients. Impact Journals LLC 2017-12-14 /pmc/articles/PMC5823590/ /pubmed/29492191 http://dx.doi.org/10.18632/oncotarget.23246 Text en Copyright: © 2018 Huang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Gerotarget (Focus on Aging)
Huang, Luying
Wang, Yi
Liu, Hua
Huang, Jianhua
Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
title Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
title_full Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
title_fullStr Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
title_full_unstemmed Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
title_short Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
title_sort local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
topic Research Paper: Gerotarget (Focus on Aging)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823590/
https://www.ncbi.nlm.nih.gov/pubmed/29492191
http://dx.doi.org/10.18632/oncotarget.23246
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AT liuhua localinjectionofhighmolecularhyaluronanpromoteswoundhealinginoldratsbyincreasingangiogenesis
AT huangjianhua localinjectionofhighmolecularhyaluronanpromoteswoundhealinginoldratsbyincreasingangiogenesis

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