Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model

DNA damage response plays a critical role in tumor growth, but little is known about its potential role in bone metabolism. We employed selective inhibitors of Chk1 and examined their effects on the proliferation and migration of mammary tumor cells as well as the development of osteoblasts and oste...

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Detalles Bibliográficos
Autores principales: Liu, Shengzhi, Liu, Yang, Minami, Kazumasa, Chen, Andy, Wan, Qiaoqiao, Yin, Yukun, Gan, Liangying, Xu, Aihua, Matsuura, Nariaki, Koizumi, Masahiko, Liu, Yunlong, Na, Sungsoo, Li, Jiliang, Nakshatri, Harikrishna, Li, Bai-Yan, Yokota, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823640/
https://www.ncbi.nlm.nih.gov/pubmed/29507695
http://dx.doi.org/10.18632/oncotarget.24286

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