Targeting JARID1B’s demethylase activity blocks a subset of its functions in oral cancer

Upregulation of the H3K4me3 demethylase JARID1B is linked to acquisition of aggressive, stem cell-like features by many cancer types. However, the utility of emerging JARID1 family inhibitors remains uncertain, in part because JARID1B’s functions in normal development and malignancy are diverse and...

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Detalles Bibliográficos
Autores principales: Facompre, Nicole D., Harmeyer, Kayla M., Sahu, Varun, Gimotty, Phyllis A., Rustgi, Anil K., Nakagawa, Hiroshi, Basu, Devraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823649/
https://www.ncbi.nlm.nih.gov/pubmed/29507668
http://dx.doi.org/10.18632/oncotarget.23739

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