Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells

KRAS mutation, one of the most common molecular alterations observed in adult carcinomas, was reported to activate the anti-oxidant program driven by the transcription factor NRF2 (Nuclear factor-erythroid 2-related factor 2). We previously observed that the antitumoral effect of Dimethyl fumarate (...

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Detalles Bibliográficos
Autores principales: Bennett Saidu, Nathaniel Edward, Bretagne, Marie, Mansuet, Audrey Lupo, Just, Pierre-Alexandre, Leroy, Karen, Cerles, Olivier, Chouzenoux, Sandrine, Nicco, Carole, Damotte, Diane, Alifano, Marco, Borghese, Bruno, Goldwasser, François, Batteux, Frédéric, Alexandre, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823659/
https://www.ncbi.nlm.nih.gov/pubmed/29507676
http://dx.doi.org/10.18632/oncotarget.24144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823659/
https://www.ncbi.nlm.nih.gov/pubmed/29507676
http://dx.doi.org/10.18632/oncotarget.24144

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