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Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity

ABSTRACT: Two series of polyurethane (PU), based on polycaprolactone (PCL) as soft segments with two different molecular weights (2000 and 530 Da), and hexamethylene diisocyanate (HDI) and 1,4-butandiol (BDO) as hard segments were synthesized to fabricate curcumin-loaded electrospun nanofibrous PCL-...

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Autores principales: Shababdoust, A., Ehsani, M., Shokrollahi, P., Zandi, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823814/
https://www.ncbi.nlm.nih.gov/pubmed/29196898
http://dx.doi.org/10.1007/s40204-017-0079-5
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author Shababdoust, A.
Ehsani, M.
Shokrollahi, P.
Zandi, M.
author_facet Shababdoust, A.
Ehsani, M.
Shokrollahi, P.
Zandi, M.
author_sort Shababdoust, A.
collection PubMed
description ABSTRACT: Two series of polyurethane (PU), based on polycaprolactone (PCL) as soft segments with two different molecular weights (2000 and 530 Da), and hexamethylene diisocyanate (HDI) and 1,4-butandiol (BDO) as hard segments were synthesized to fabricate curcumin-loaded electrospun nanofibrous PCL-based PU substrate. Chemical structures of the synthesized PUs were characterized by FTIR and NMR spectroscopy techniques. The thermal properties were analyzed by differential scanning calorimetry (DSC) and surface hydrophilicity was studied by static contact angle and bulk hydrophilicity was evaluated by water uptake test. Thereafter, bead-free PU nanofiberous substrate containing curcumin was fabricated by electrospinning and morphology of the mats was observed by scanning electron microscopy (SEM). Mechanical properties of the electrospun mats in comparison with polymeric films were assessed by a universal test machine. The in vitro release of curcumin was studied by UV–Vis spectroscopy. The optical density of the bacterial solutions was used to evaluate the antibacterial activity of the curcumin-loaded nanofibrous mats against Escherichia coli (E-coli ATCC: 25922). The results showed that curcumin-loaded PU synthesized by PCL with molecular weight of 2000 Da displayed better mechanical properties as well as better antibacterial properties in wound dressing application. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-58238142018-02-28 Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity Shababdoust, A. Ehsani, M. Shokrollahi, P. Zandi, M. Prog Biomater Original Research ABSTRACT: Two series of polyurethane (PU), based on polycaprolactone (PCL) as soft segments with two different molecular weights (2000 and 530 Da), and hexamethylene diisocyanate (HDI) and 1,4-butandiol (BDO) as hard segments were synthesized to fabricate curcumin-loaded electrospun nanofibrous PCL-based PU substrate. Chemical structures of the synthesized PUs were characterized by FTIR and NMR spectroscopy techniques. The thermal properties were analyzed by differential scanning calorimetry (DSC) and surface hydrophilicity was studied by static contact angle and bulk hydrophilicity was evaluated by water uptake test. Thereafter, bead-free PU nanofiberous substrate containing curcumin was fabricated by electrospinning and morphology of the mats was observed by scanning electron microscopy (SEM). Mechanical properties of the electrospun mats in comparison with polymeric films were assessed by a universal test machine. The in vitro release of curcumin was studied by UV–Vis spectroscopy. The optical density of the bacterial solutions was used to evaluate the antibacterial activity of the curcumin-loaded nanofibrous mats against Escherichia coli (E-coli ATCC: 25922). The results showed that curcumin-loaded PU synthesized by PCL with molecular weight of 2000 Da displayed better mechanical properties as well as better antibacterial properties in wound dressing application. GRAPHICAL ABSTRACT: [Image: see text] Springer Berlin Heidelberg 2017-12-01 /pmc/articles/PMC5823814/ /pubmed/29196898 http://dx.doi.org/10.1007/s40204-017-0079-5 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Shababdoust, A.
Ehsani, M.
Shokrollahi, P.
Zandi, M.
Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity
title Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity
title_full Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity
title_fullStr Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity
title_full_unstemmed Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity
title_short Fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity
title_sort fabrication of curcumin-loaded electrospun nanofiberous polyurethanes with anti-bacterial activity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823814/
https://www.ncbi.nlm.nih.gov/pubmed/29196898
http://dx.doi.org/10.1007/s40204-017-0079-5
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