Cargando…
Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
Childhood maltreatment (CM) can increase the risk of adverse health consequences in adulthood. A deeper insight in underlying biological pathways would be of high clinical relevance for early detection and intervention. The untargeted investigation of all detectable metabolites and lipids in biologi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823924/ https://www.ncbi.nlm.nih.gov/pubmed/29472571 http://dx.doi.org/10.1038/s41598-018-21763-6 |
_version_ | 1783301956294410240 |
---|---|
author | Koenig, Alexandra M Karabatsiakis, Alexander Stoll, Thomas Wilker, Sarah Hennessy, Thomas Hill, Michelle M Kolassa, Iris-Tatjana |
author_facet | Koenig, Alexandra M Karabatsiakis, Alexander Stoll, Thomas Wilker, Sarah Hennessy, Thomas Hill, Michelle M Kolassa, Iris-Tatjana |
author_sort | Koenig, Alexandra M |
collection | PubMed |
description | Childhood maltreatment (CM) can increase the risk of adverse health consequences in adulthood. A deeper insight in underlying biological pathways would be of high clinical relevance for early detection and intervention. The untargeted investigation of all detectable metabolites and lipids in biological samples represents a promising new avenue to identify so far unknown biological pathways associated with CM. Using an untargeted approach, liquid chromatography-mass spectrometry (LC-MS) was performed on peripheral blood serum samples collected three months postpartum from 105 women with varying degrees of CM exposure. Comprehensive univariate and multivariate statistical analyses consistently identified eight biomarker candidates putatively belonging to antioxidant-, lipid-, and endocannabinoid-associated pathways, which differentiated between women with and without CM. Classification algorithms allowed for clear prediction of the CM status with high accuracy scores (~80–90%). Similar results were obtained when excluding all women with a lifetime psychiatric diagnosis. In order to confirm the identities of these promising biomarker candidates, LC-MS/MS analysis was applied, confirming one of the metabolites as bilirubin IXa, a potent antioxidant with immunomodulatory properties. In sum, our results suggest novel pathways that could explain long-term effects of CM on health and disease by influencing biological patterns associated with energy metabolism, inflammation, and oxidative stress. |
format | Online Article Text |
id | pubmed-5823924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58239242018-02-26 Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study Koenig, Alexandra M Karabatsiakis, Alexander Stoll, Thomas Wilker, Sarah Hennessy, Thomas Hill, Michelle M Kolassa, Iris-Tatjana Sci Rep Article Childhood maltreatment (CM) can increase the risk of adverse health consequences in adulthood. A deeper insight in underlying biological pathways would be of high clinical relevance for early detection and intervention. The untargeted investigation of all detectable metabolites and lipids in biological samples represents a promising new avenue to identify so far unknown biological pathways associated with CM. Using an untargeted approach, liquid chromatography-mass spectrometry (LC-MS) was performed on peripheral blood serum samples collected three months postpartum from 105 women with varying degrees of CM exposure. Comprehensive univariate and multivariate statistical analyses consistently identified eight biomarker candidates putatively belonging to antioxidant-, lipid-, and endocannabinoid-associated pathways, which differentiated between women with and without CM. Classification algorithms allowed for clear prediction of the CM status with high accuracy scores (~80–90%). Similar results were obtained when excluding all women with a lifetime psychiatric diagnosis. In order to confirm the identities of these promising biomarker candidates, LC-MS/MS analysis was applied, confirming one of the metabolites as bilirubin IXa, a potent antioxidant with immunomodulatory properties. In sum, our results suggest novel pathways that could explain long-term effects of CM on health and disease by influencing biological patterns associated with energy metabolism, inflammation, and oxidative stress. Nature Publishing Group UK 2018-02-22 /pmc/articles/PMC5823924/ /pubmed/29472571 http://dx.doi.org/10.1038/s41598-018-21763-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Koenig, Alexandra M Karabatsiakis, Alexander Stoll, Thomas Wilker, Sarah Hennessy, Thomas Hill, Michelle M Kolassa, Iris-Tatjana Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study |
title | Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study |
title_full | Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study |
title_fullStr | Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study |
title_full_unstemmed | Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study |
title_short | Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study |
title_sort | serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823924/ https://www.ncbi.nlm.nih.gov/pubmed/29472571 http://dx.doi.org/10.1038/s41598-018-21763-6 |
work_keys_str_mv | AT koenigalexandram serumprofilechangesinpostpartumwomenwithahistoryofchildhoodmaltreatmentacombinedmetaboliteandlipidfingerprintingstudy AT karabatsiakisalexander serumprofilechangesinpostpartumwomenwithahistoryofchildhoodmaltreatmentacombinedmetaboliteandlipidfingerprintingstudy AT stollthomas serumprofilechangesinpostpartumwomenwithahistoryofchildhoodmaltreatmentacombinedmetaboliteandlipidfingerprintingstudy AT wilkersarah serumprofilechangesinpostpartumwomenwithahistoryofchildhoodmaltreatmentacombinedmetaboliteandlipidfingerprintingstudy AT hennessythomas serumprofilechangesinpostpartumwomenwithahistoryofchildhoodmaltreatmentacombinedmetaboliteandlipidfingerprintingstudy AT hillmichellem serumprofilechangesinpostpartumwomenwithahistoryofchildhoodmaltreatmentacombinedmetaboliteandlipidfingerprintingstudy AT kolassairistatjana serumprofilechangesinpostpartumwomenwithahistoryofchildhoodmaltreatmentacombinedmetaboliteandlipidfingerprintingstudy |