EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

Ciliogenesis is generally inhibited in dividing cells, however, it has been unclear which signaling cascades regulate the phenomenon. Here, we report that epidermal growth factor receptor (EGFR) kinase suppresses ciliogenesis by directly phosphorylating the deubiquitinase USP8 on Tyr-717 and Tyr-810...

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Detalles Bibliográficos
Autores principales: Kasahara, Kousuke, Aoki, Hiromasa, Kiyono, Tohru, Wang, Shujie, Kagiwada, Harumi, Yuge, Mizuki, Tanaka, Toshio, Nishimura, Yuhei, Mizoguchi, Akira, Goshima, Naoki, Inagaki, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823934/
https://www.ncbi.nlm.nih.gov/pubmed/29472535
http://dx.doi.org/10.1038/s41467-018-03117-y

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