Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This “r...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider, Benjamin, Balbas‐Martinez, Violeta, Jergens, Albert E., Troconiz, Inaki F., Allenspach, Karin, Mochel, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824107/
https://www.ncbi.nlm.nih.gov/pubmed/29178333
http://dx.doi.org/10.1002/psp4.12262
_version_ 1783301984651051008
author Schneider, Benjamin
Balbas‐Martinez, Violeta
Jergens, Albert E.
Troconiz, Inaki F.
Allenspach, Karin
Mochel, Jonathan P.
author_facet Schneider, Benjamin
Balbas‐Martinez, Violeta
Jergens, Albert E.
Troconiz, Inaki F.
Allenspach, Karin
Mochel, Jonathan P.
author_sort Schneider, Benjamin
collection PubMed
description There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This “reverse translational” approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species.
format Online
Article
Text
id pubmed-5824107
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-58241072018-02-26 Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative Schneider, Benjamin Balbas‐Martinez, Violeta Jergens, Albert E. Troconiz, Inaki F. Allenspach, Karin Mochel, Jonathan P. CPT Pharmacometrics Syst Pharmacol Perspective There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This “reverse translational” approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species. John Wiley and Sons Inc. 2017-11-27 2018-02 /pmc/articles/PMC5824107/ /pubmed/29178333 http://dx.doi.org/10.1002/psp4.12262 Text en © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspective
Schneider, Benjamin
Balbas‐Martinez, Violeta
Jergens, Albert E.
Troconiz, Inaki F.
Allenspach, Karin
Mochel, Jonathan P.
Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative
title Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative
title_full Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative
title_fullStr Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative
title_full_unstemmed Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative
title_short Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative
title_sort model‐based reverse translation between veterinary and human medicine: the one health initiative
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824107/
https://www.ncbi.nlm.nih.gov/pubmed/29178333
http://dx.doi.org/10.1002/psp4.12262
work_keys_str_mv AT schneiderbenjamin modelbasedreversetranslationbetweenveterinaryandhumanmedicinetheonehealthinitiative
AT balbasmartinezvioleta modelbasedreversetranslationbetweenveterinaryandhumanmedicinetheonehealthinitiative
AT jergensalberte modelbasedreversetranslationbetweenveterinaryandhumanmedicinetheonehealthinitiative
AT troconizinakif modelbasedreversetranslationbetweenveterinaryandhumanmedicinetheonehealthinitiative
AT allenspachkarin modelbasedreversetranslationbetweenveterinaryandhumanmedicinetheonehealthinitiative
AT mocheljonathanp modelbasedreversetranslationbetweenveterinaryandhumanmedicinetheonehealthinitiative

Ejemplares similares