a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity

[Image: see text] Protein prenylation is a post-translational modification that involves the addition of one or two isoprenoid groups to the C-terminus of selected proteins using either farnesyl diphosphate or geranylgeranyl diphosphate. Three crucial enzymatic steps are involved in the processing o...

Descripción completa

Detalles Bibliográficos
Autores principales: Diaz-Rodriguez, Veronica, Hsu, Erh-Ting, Ganusova, Elena, Werst, Elena R., Becker, Jeffrey M., Hrycyna, Christine A., Distefano, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824361/
https://www.ncbi.nlm.nih.gov/pubmed/29188996
http://dx.doi.org/10.1021/acs.bioconjchem.7b00648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824361/
https://www.ncbi.nlm.nih.gov/pubmed/29188996
http://dx.doi.org/10.1021/acs.bioconjchem.7b00648

Ejemplares similares