Wild‐type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition

Inflammation is the major cause of endothelial barrier hyper‐permeability, associated with acute lung injury and acute respiratory distress syndrome. This study reports that p53 “orchestrates” the defence of vascular endothelium against LPS, by mediating the opposing actions of Rac1 and RhoA in pulm...

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Detalles Bibliográficos
Autores principales: Barabutis, Nektarios, Dimitropoulou, Christiana, Gregory, Betsy, Catravas, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824363/
https://www.ncbi.nlm.nih.gov/pubmed/29363851
http://dx.doi.org/10.1111/jcmm.13460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824363/
https://www.ncbi.nlm.nih.gov/pubmed/29363851
http://dx.doi.org/10.1111/jcmm.13460

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