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Wild‐type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition
Inflammation is the major cause of endothelial barrier hyper‐permeability, associated with acute lung injury and acute respiratory distress syndrome. This study reports that p53 “orchestrates” the defence of vascular endothelium against LPS, by mediating the opposing actions of Rac1 and RhoA in pulm...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824363/ https://www.ncbi.nlm.nih.gov/pubmed/29363851 http://dx.doi.org/10.1111/jcmm.13460 |