SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy

D‐serine is a predominant N‐methyl‐D‐aspartate receptor co‐agonist with glutamate, and excessive activation of the receptor plays a substantial role in epileptic seizures. Serine racemase (SRR) is responsible for transforming L‐serine to D‐serine. In this study, we aimed to investigate the genetic r...

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Detalles Bibliográficos
Autores principales: Tao, Hua, Zhou, Xu, Xie, Qian, Ma, Zhonghua, Sun, Fuhai, Cui, Lili, Cai, Yujie, Ma, Guoda, Fu, Jiawu, Liu, Zhou, Li, You, Zhou, Haihong, Zhao, Jianghao, Chen, Yanyan, Mai, Hui, Chen, Ying, Chen, Jun, Qi, Wei, Sun, Chaowen, Zhao, Bin, Li, Keshen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824374/
https://www.ncbi.nlm.nih.gov/pubmed/29363864
http://dx.doi.org/10.1111/jcmm.13473

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