H3 relaxin inhibits the collagen synthesis via ROS‐ and P2X7R‐mediated NLRP3 inflammasome activation in cardiac fibroblasts under high glucose

Excessive production of reactive oxygen species (ROS) and P2X7R activation induced by high glucose increases NLRP3 inflammasome activation, which contributes to the pathogenesis of diabetic cardiomyopathy. Although H3 relaxin has been shown to inhibit cardiac fibrosis induced by isoproterenol, the m...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaohui, Fu, Yu, Li, Hui, Shen, Li, Chang, Qing, Pan, Liya, Hong, Siting, Yin, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824385/
https://www.ncbi.nlm.nih.gov/pubmed/29314607
http://dx.doi.org/10.1111/jcmm.13464

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