Cargando…

A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda

BACKGROUND: While the combination of nifurtimox and eflornithine (NECT) is currently recommended for the treatment of the late stage human African trypansomiasis (HAT), single-agent eflornithine was still the treatment of choice when this trial commenced. This study intended to provide supportive ev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kansiime, Freddie, Adibaku, Seraphine, Wamboga, Charles, Idi, Franklin, Kato, Charles Drago, Yamuah, Lawrence, Vaillant, Michel, Kioy, Deborah, Olliaro, Piero, Matovu, Enock
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824494/ https://www.ncbi.nlm.nih.gov/pubmed/29471865 http://dx.doi.org/10.1186/s13071-018-2634-x

Ejemplares similares

720. Efficacy of Nifurtimox + Eflornithine in the Treatment of African Trypanosomiasis. Systematic Review
por: Hidalgo, Jessica, et al.
Publicado: (2021)

In-Hospital Safety in Field Conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. b. gambiense Sleeping Sickness
por: Schmid, Caecilia, et al.
Publicado: (2012)

Efficacy and Toxicity of Fexinidazole and Nifurtimox Plus Eflornithine in the Treatment of African Trypanosomiasis: A Systematic Review
por: Hidalgo, Jessica, et al.
Publicado: (2021)

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
por: Vincent, Isabel M., et al.
Publicado: (2012)

Nifurtimox plus Eflornithine for Late-Stage Sleeping Sickness in Uganda: A Case Series
por: Checchi, Francesco, et al.
Publicado: (2007)

Prescription of concomitant medications in patients treated with Nifurtimox Eflornithine Combination Therapy (NECT) for T.b. gambiense second stage sleeping sickness in the Democratic Republic of the Congo
por: Kuemmerle, Andrea, et al.
Publicado: (2020)

Effectiveness of Nifurtimox Eflornithine Combination Therapy (NECT) in T. b. gambiense second stage sleeping sickness patients in the Democratic Republic of Congo: Report from a field study
por: Kuemmerle, Andrea, et al.
Publicado: (2021)

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
por: Baker, Nicola, et al.
Publicado: (2011)

Enantiospecific antitrypanosomal in vitro activity of eflornithine
por: Boberg, Mikael, et al.
Publicado: (2021)

Chiral Chromatographic Isolation on Milligram Scale of the Human African Trypanosomiasis Treatment d- and l-Eflornithine
por: Boberg, Mikael, et al.
Publicado: (2020)

Enhanced passive screening and diagnosis for gambiense human African trypanosomiasis in north-western Uganda – Moving towards elimination
por: Wamboga, Charles, et al.
Publicado: (2017)

The blood–brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain(1)
por: Sanderson, Lisa, et al.
Publicado: (2008)

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
por: Vincent, Isabel M., et al.
Publicado: (2010)

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas
por: Levin, Victor A, et al.
Publicado: (2018)

Serological tests for gambiense human African trypanosomiasis detect antibodies in cattle
por: Matovu, Enock, et al.
Publicado: (2017)

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells
por: Yam, Noymi, et al.
Publicado: (2020)

Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria
por: El-Saber Batiha, Gaber, et al.
Publicado: (2020)

Application of Hantzsch reaction for sensitive determination of eflornithine in cream, plasma and urine samples
por: Almahri, Albandary, et al.
Publicado: (2021)

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application
por: Almuwallad, Shuruq S., et al.
Publicado: (2023)

The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis
por: Jackson, Andrew P., et al.
Publicado: (2010)

Implications of Heterogeneous Biting Exposure and Animal Hosts on Trypanosomiasis brucei gambiense Transmission and Control
por: Stone, Chris M., et al.
Publicado: (2015)

Use of Eflornithine (DFMO) in the Treatment of Early Alzheimer's Disease: A Compassionate Use, Single-Case Study
por: Alber, Jessica, et al.
Publicado: (2018)

Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease
por: Rajasekaran, Surender, et al.
Publicado: (2021)

African Trypanosomiasis Gambiense, Italy
por: Bisoffi, Zeno, et al.
Publicado: (2005)

Target product profile: diagnostic test for Trypanosoma brucei gambiense
por: Priotto, Gerardo, et al.
Publicado: (2023)

Unusual MRI Findings in African Trypanosoma brucei gambiense Trypanosomiasis: Dentate Nuclei and Hypothalamic Lesions
por: Boukobza, Monique, et al.
Publicado: (2020)

DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27(Kip1) activity in neuroblastoma
por: KOOMOA, DANA-LYNN T., et al.
Publicado: (2013)

Target product profile: Trypanosoma brucei gambiense test to verify elimination
por: Priotto, Gerardo, et al.
Publicado: (2023)

Cerebrospinal Fluid Neopterin as Marker of the Meningo-Encephalitic Stage of Trypanosoma brucei gambiense Sleeping Sickness
por: Tiberti, Natalia, et al.
Publicado: (2012)

3,3'-Diindolylmethane plus Eflornithine suppress DNA Replication and Cell Cycle in Esophageal Squamous Cell Carcinoma in vivo
por: Ma, Fayang, et al.
Publicado: (2022)

Eflornithine for chemoprevention in the high-risk population of colorectal cancer: a systematic review and meta-analysis with trial sequential analysis
por: Yang, Lifeng, et al.
Publicado: (2023)

Target product profile: Trypanosoma brucei gambiense test for low-prevalence settings
por: Priotto, Gerardo, et al.
Publicado: (2023)

Treatment options for second-stage gambiense human African trypanosomiasis
por: Eperon, Gilles, et al.
Publicado: (2014)

Molecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea
por: Cordon-Obras, Carlos, et al.
Publicado: (2015)

Performance evaluation of a prototype rapid diagnostic test for combined detection of gambiense human African trypanosomiasis and malaria
por: Lumbala, Crispin, et al.
Publicado: (2020)

Neopterin Is a Cerebrospinal Fluid Marker for Treatment Outcome Evaluation in Patients Affected by Trypanosoma brucei gambiense Sleeping Sickness
por: Tiberti, Natalia, et al.
Publicado: (2013)

Trypanosoma brucei gambiense-iELISA: A Promising New Test for the Post-Elimination Monitoring of Human African Trypanosomiasis
por: Geerts, Manon, et al.
Publicado: (2020)

Gambiense human African trypanosomiasis: the bumpy road to elimination
por: Hasker, Epco, et al.
Publicado: (2022)

Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal
por: Kazibwe, Anne J. N., et al.
Publicado: (2009)

Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies
por: Ndung’u, Joseph Mathu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ethffvj8p35b4edbir3nbbnf9j