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Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration
PURPOSE: To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD). METHODS: In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re n...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824750/ https://www.ncbi.nlm.nih.gov/pubmed/29503524 http://dx.doi.org/10.2147/OPTH.S151999 |
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author | Takahashi, Hidenori Inoue, Yuji Tan, Xue Inoda, Satoru Sakamoto, Shinichi Arai, Yusuke Yanagi, Yasuo Fujino, Yujiro Kawashima, Hidetoshi |
author_facet | Takahashi, Hidenori Inoue, Yuji Tan, Xue Inoda, Satoru Sakamoto, Shinichi Arai, Yusuke Yanagi, Yasuo Fujino, Yujiro Kawashima, Hidetoshi |
author_sort | Takahashi, Hidenori |
collection | PubMed |
description | PURPOSE: To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD). METHODS: In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen) and maintained initial visual acuity gain were analyzed. The following 5 parameters were measured at the foveal center: CMT (distance from the inner limiting membrane [ILM] to Bruch’s membrane); central retinal thickness (CRT; distance from the ILM to the inner limit of the retinal pigment epithelium or subretinal fluid [SRF]); SRF thickness (SRFT); pigment epithelium detachment thickness (PEDT); and CCT. The correlation between the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) and the 5 parameters was examined with generalized estimating equations. RESULTS: CMT, CRT, and CCT were negatively correlated with logMAR BCVA (P=0.031, 0.023, and 0.036, respectively) when only CMT values less than the thickness that maximized visual acuity for each eye were used for the analysis. Each 100-μm reduction in CMT, CRT, or CCT improved logMAR BCVA by −0.1, −0.08, or −0.07, respectively. SRFT and PEDT were not correlated with BCVA. The median CMT that maximized the visual acuity was 230 μm. CONCLUSION: Dry macula with CMT <230 μm was associated with temporary decrease in visual acuity in AMD patients whose visual acuity was maintained with PRN regimen. |
format | Online Article Text |
id | pubmed-5824750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58247502018-03-02 Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration Takahashi, Hidenori Inoue, Yuji Tan, Xue Inoda, Satoru Sakamoto, Shinichi Arai, Yusuke Yanagi, Yasuo Fujino, Yujiro Kawashima, Hidetoshi Clin Ophthalmol Original Research PURPOSE: To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD). METHODS: In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen) and maintained initial visual acuity gain were analyzed. The following 5 parameters were measured at the foveal center: CMT (distance from the inner limiting membrane [ILM] to Bruch’s membrane); central retinal thickness (CRT; distance from the ILM to the inner limit of the retinal pigment epithelium or subretinal fluid [SRF]); SRF thickness (SRFT); pigment epithelium detachment thickness (PEDT); and CCT. The correlation between the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) and the 5 parameters was examined with generalized estimating equations. RESULTS: CMT, CRT, and CCT were negatively correlated with logMAR BCVA (P=0.031, 0.023, and 0.036, respectively) when only CMT values less than the thickness that maximized visual acuity for each eye were used for the analysis. Each 100-μm reduction in CMT, CRT, or CCT improved logMAR BCVA by −0.1, −0.08, or −0.07, respectively. SRFT and PEDT were not correlated with BCVA. The median CMT that maximized the visual acuity was 230 μm. CONCLUSION: Dry macula with CMT <230 μm was associated with temporary decrease in visual acuity in AMD patients whose visual acuity was maintained with PRN regimen. Dove Medical Press 2018-02-20 /pmc/articles/PMC5824750/ /pubmed/29503524 http://dx.doi.org/10.2147/OPTH.S151999 Text en © 2018 Takahashi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Takahashi, Hidenori Inoue, Yuji Tan, Xue Inoda, Satoru Sakamoto, Shinichi Arai, Yusuke Yanagi, Yasuo Fujino, Yujiro Kawashima, Hidetoshi Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
title | Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
title_full | Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
title_fullStr | Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
title_full_unstemmed | Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
title_short | Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
title_sort | visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824750/ https://www.ncbi.nlm.nih.gov/pubmed/29503524 http://dx.doi.org/10.2147/OPTH.S151999 |
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