Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance

Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to play key roles in cellular homeostasis by regulating a variety of cellular processes inclu...

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Detalles Bibliográficos
Autores principales: Gertman, Or, Omer, Dotan, Hendler, Adi, Stein, Daniel, Onn, Lior, Khukhin, Yana, Portillo, Miguel, Zarivach, Raz, Cohen, Haim Y., Toiber, Debra, Aharoni, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824787/
https://www.ncbi.nlm.nih.gov/pubmed/29476161
http://dx.doi.org/10.1038/s41598-018-21887-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824787/
https://www.ncbi.nlm.nih.gov/pubmed/29476161
http://dx.doi.org/10.1038/s41598-018-21887-9

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