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Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824793/ https://www.ncbi.nlm.nih.gov/pubmed/29476170 http://dx.doi.org/10.1038/s41598-018-22027-z |
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author | Zheng, M. Cao, Z. Vorobyeva, Y. Manrique, P. Song, C. Johnson, N. F. |
author_facet | Zheng, M. Cao, Z. Vorobyeva, Y. Manrique, P. Song, C. Johnson, N. F. |
author_sort | Zheng, M. |
collection | PubMed |
description | We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the structural and functional networks. Aging sees these structural and functional networks gradually diverge in terms of their small-worldness and eventually their connectivity. Dying emerges as an extended process associated with the formation of large but disjoint functional sub-networks together with an increasingly detached core. Our mathematical model quantifies the very different impacts that interventions will have on the overall lifetime, period of initial growth, peak of potency, and duration of old age, depending on when and how they are administered. In addition to their direct relevance to online extremism, our findings may offer insight into aging in other network systems of comparable complexity for which extensive in vivo data is not yet available. |
format | Online Article Text |
id | pubmed-5824793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58247932018-03-01 Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death Zheng, M. Cao, Z. Vorobyeva, Y. Manrique, P. Song, C. Johnson, N. F. Sci Rep Article We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the structural and functional networks. Aging sees these structural and functional networks gradually diverge in terms of their small-worldness and eventually their connectivity. Dying emerges as an extended process associated with the formation of large but disjoint functional sub-networks together with an increasingly detached core. Our mathematical model quantifies the very different impacts that interventions will have on the overall lifetime, period of initial growth, peak of potency, and duration of old age, depending on when and how they are administered. In addition to their direct relevance to online extremism, our findings may offer insight into aging in other network systems of comparable complexity for which extensive in vivo data is not yet available. Nature Publishing Group UK 2018-02-23 /pmc/articles/PMC5824793/ /pubmed/29476170 http://dx.doi.org/10.1038/s41598-018-22027-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zheng, M. Cao, Z. Vorobyeva, Y. Manrique, P. Song, C. Johnson, N. F. Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death |
title | Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death |
title_full | Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death |
title_fullStr | Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death |
title_full_unstemmed | Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death |
title_short | Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death |
title_sort | multiscale dynamical network mechanisms underlying aging of an online organism from birth to death |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824793/ https://www.ncbi.nlm.nih.gov/pubmed/29476170 http://dx.doi.org/10.1038/s41598-018-22027-z |
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