Cargando…

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome

Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased food intake or obesity. Mice with a microdeletion encompassing the Snord116 clu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Polex-Wolf, Joseph, Lam, Brian Y.H., Larder, Rachel, Tadross, John, Rimmington, Debra, Bosch, Fàtima, Cenzano, Verónica Jiménez, Ayuso, Eduard, Ma, Marcella K.L., Rainbow, Kara, Coll, Anthony P., O’Rahilly, Stephen, Yeo, Giles S.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824864/ https://www.ncbi.nlm.nih.gov/pubmed/29376887 http://dx.doi.org/10.1172/JCI97007

Ejemplares similares

SNORD116 and growth hormone therapy impact IGFBP7 in Prader–Willi syndrome
por: Eddiry, Sanaa, et al.
Publicado: (2021)

Phylogenetic and Molecular Analyses Identify SNORD116 Targets Involved in the Prader–Willi Syndrome
por: Baldini, Laeya, et al.
Publicado: (2021)

Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116(m+/p−) and Snord116(m−/p−) Mouse Models of Prader–Willi Syndrome
por: Knott, Brittney, et al.
Publicado: (2022)

An Atypical 15q11.2 Microdeletion Not Involving SNORD116 Resulting in Prader–Willi Syndrome
por: Crenshaw, Molly M., et al.
Publicado: (2023)

Hyperphagia and Obesity in Prader–Willi Syndrome: PCSK1 Deficiency and Beyond?
por: Ramos-Molina, Bruno, et al.
Publicado: (2018)

Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome
por: Miller, Jennifer L., et al.
Publicado: (2015)

Development and validation of the Pediatric-Youth Hyperphagia Assessment for Prader-Willi syndrome
por: Cho, Sung Yoon, et al.
Publicado: (2022)

The SNORD115 (H/MBII-52) and SNORD116 (H/MBII-85) gene clusters at the imprinted Prader–Willi locus generate canonical box C/D snoRNAs
por: Bortolin-Cavaillé, Marie-Line, et al.
Publicado: (2012)

Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader–Willi Syndrome Etiology
por: Ariyanfar, Shadi, et al.
Publicado: (2022)

Identifying key underlying regulatory networks and predicting targets of orphan C/D box SNORD116 snoRNAs in Prader-Willi syndrome
por: Gilmore, Rachel B., et al.
Publicado: (2023)

SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice
por: Ding, Feng, et al.
Publicado: (2008)

Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader‐Willi syndrome
por: Kweh, Frederick A., et al.
Publicado: (2023)

Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader–Willi syndrome
por: Davies, Jennifer R., et al.
Publicado: (2015)

Characteristics and relationship between hyperphagia, anxiety, behavioral challenges and caregiver burden in Prader-Willi syndrome
por: Kayadjanian, Nathalie, et al.
Publicado: (2021)

The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome
por: Licenziati, Maria Rosaria, et al.
Publicado: (2022)

Phylogenetic Analysis of the SNORD116 Locus
por: Kocher, Matthew A., et al.
Publicado: (2017)

Intranasal Carbetocin Reduces Hyperphagia, Anxiousness, and Distress in Prader-Willi Syndrome: CARE-PWS Phase 3 Trial
por: Roof, Elizabeth, et al.
Publicado: (2023)

Analysis of Hyperphagia Questionnaire for Clinical Trials (HQ-CT) scores in typically developing individuals and those with Prader-Willi syndrome
por: Matesevac, Lisa, et al.
Publicado: (2023)

SUN-608 Juvenile Toxicity Study of Livoletide: A Peptide Analogue of Unacylated Ghrelin for the Treatment of Hyperphagia in Prader-Willi Syndrome
por: Xu, Howard, et al.
Publicado: (2020)

Snord116 is critical in the regulation of food intake and body weight
por: Qi, Yue, et al.
Publicado: (2016)

MON-102 Nonclinical Development of AZP-531 (Livoletide): A Peptide Analog of Unacylated Ghrelin for the Treatment of Hyperphagia in Prader-Willi Syndrome
por: Milano, Stephane, et al.
Publicado: (2019)

Three Siblings with Prader-Willi Syndrome: Brief Review of Sleep and Prader-Willi Syndrome
por: Bingeliene, Arina, et al.
Publicado: (2015)

Topline Results of the CARE-PWS Phase 3 Study: Intranasal Carbetocin Improves Hyperphagia and Anxiety and Distress Symptoms in Prader-Willi Syndrome (PWS)
por: Ryman, Davis, et al.
Publicado: (2021)

Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex
por: Coulson, Rochelle L., et al.
Publicado: (2018)

Genetics of Prader-Willi syndrome and Prader-Will-Like syndrome
por: Cheon, Chong Kun
Publicado: (2016)

Epigenetics in Prader-Willi Syndrome
por: Mendiola, Aron Judd P., et al.
Publicado: (2021)

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing
por: Dowsett, Georgina K.C., et al.
Publicado: (2021)

Prader-Willi Syndrome: Clinical Aspects
por: Elena, Grechi, et al.
Publicado: (2012)

Hyperprolactinemia in Adults with Prader-Willi Syndrome
por: Sjöström, Anna, et al.
Publicado: (2021)

Approach to the Patient With Prader–Willi Syndrome
por: Höybye, Charlotte, et al.
Publicado: (2022)

Sleep Consequences of Prader-Willi Syndrome
por: Itani, Reem, et al.
Publicado: (2023)

Causes of Death in Prader-Willi Syndrome: Prader-Willi Syndrome Association (USA) 40-Year Mortality Survey
por: Butler, Merlin G., et al.
Publicado: (2016)

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
por: Lam, Brian Y.H., et al.
Publicado: (2017)

SUN-609 Livoletide (AZP-531), an Unacylated Ghrelin Analogue, Improves Hyperphagia and Food-Related Behaviors Both in Obese and Non-Obese People with Prader-Willi Syndrome
por: Harisseh, Rania, et al.
Publicado: (2020)

Distinct promoter regions of the oxytocin receptor gene are hypomethylated in Prader-Willi syndrome and in Prader-Willi syndrome associated psychosis
por: Heseding, Hannah M., et al.
Publicado: (2022)

Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency
por: Corander, Marcus P., et al.
Publicado: (2011)

Prader-Willi syndrome: A primer for clinicians
por: Cataletto, Mary, et al.
Publicado: (2011)

Prader-Willi Syndrome and Growth Hormone Deficiency
por: Aycan, Zehra, et al.
Publicado: (2014)

Endocrine manifestations and management of Prader-Willi syndrome
por: Emerick, Jill E, et al.
Publicado: (2013)

Clinical and laboratory characteristics of Prader-Willi syndrome
por: Thao, Bui Phuong, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_94uh7dh1uqhb19bn2vda7tg8qu