Construction and characterization of bacterial artificial chromosomes harboring the full-length genome of a highly attenuated vaccinia virus LC16m8

LC16m8 (m8), a highly attenuated vaccinia virus (VAC) strain, was developed as a smallpox vaccine, and its safety and immunogenicity have been confirmed. Here, we aimed to develop a system that recovers infectious m8 from a bacterial artificial chromosome (BAC) that retains the full-length viral gen...

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Detalles Bibliográficos
Autores principales: Yoshikawa, Tomoki, Fujii, Hikaru, Okutani, Akiko, Shibamura, Miho, Omura, Natsumi, Egawa, Kazutaka, Kato, Hirofumi, Inagaki, Takuya, Harada, Shizuko, Yamada, Souichi, Morikawa, Shigeru, Saijo, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825015/
https://www.ncbi.nlm.nih.gov/pubmed/29474493
http://dx.doi.org/10.1371/journal.pone.0192725

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