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Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices
Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825016/ https://www.ncbi.nlm.nih.gov/pubmed/29474357 http://dx.doi.org/10.1371/journal.pone.0192369 |
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author | Bernard, Lise Eljezi, Teuta Clauson, Hélène Lambert, Céline Bouattour, Yassine Chennell, Philip Pereira, Bruno Sautou, Valérie |
author_facet | Bernard, Lise Eljezi, Teuta Clauson, Hélène Lambert, Céline Bouattour, Yassine Chennell, Philip Pereira, Bruno Sautou, Valérie |
author_sort | Bernard, Lise |
collection | PubMed |
description | Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients. The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated. In this study, we evaluated the impact of different flow rates on the release of the different plasticizers during an infusion procedure in order to assess if they could expose the patients to more toxic amounts of plasticizers. Migration assays with different PVC infusion sets and extension lines were performed with different flow rates that are used in clinical practice during 1h, 2h, 4h, 8h and 24h, using a lipophilic drug simulant. From a clinical point of view, the results showed that, regardless of the plasticizer, the faster the flow rate, the higher the infused volume and the higher the quantities of plasticizers released, both from infusion sets and extension lines, leading to higher patient exposure. However, physically, there was no significant difference of the migration kinetics linked to the flow rate for a same medical device, reflecting complex interactions between the PVC matrix and the simulant. The migration was especially dependent on the nature and the composition of the medical device. |
format | Online Article Text |
id | pubmed-5825016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58250162018-03-19 Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices Bernard, Lise Eljezi, Teuta Clauson, Hélène Lambert, Céline Bouattour, Yassine Chennell, Philip Pereira, Bruno Sautou, Valérie PLoS One Research Article Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients. The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated. In this study, we evaluated the impact of different flow rates on the release of the different plasticizers during an infusion procedure in order to assess if they could expose the patients to more toxic amounts of plasticizers. Migration assays with different PVC infusion sets and extension lines were performed with different flow rates that are used in clinical practice during 1h, 2h, 4h, 8h and 24h, using a lipophilic drug simulant. From a clinical point of view, the results showed that, regardless of the plasticizer, the faster the flow rate, the higher the infused volume and the higher the quantities of plasticizers released, both from infusion sets and extension lines, leading to higher patient exposure. However, physically, there was no significant difference of the migration kinetics linked to the flow rate for a same medical device, reflecting complex interactions between the PVC matrix and the simulant. The migration was especially dependent on the nature and the composition of the medical device. Public Library of Science 2018-02-23 /pmc/articles/PMC5825016/ /pubmed/29474357 http://dx.doi.org/10.1371/journal.pone.0192369 Text en © 2018 Bernard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bernard, Lise Eljezi, Teuta Clauson, Hélène Lambert, Céline Bouattour, Yassine Chennell, Philip Pereira, Bruno Sautou, Valérie Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices |
title | Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices |
title_full | Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices |
title_fullStr | Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices |
title_full_unstemmed | Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices |
title_short | Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices |
title_sort | effects of flow rate on the migration of different plasticizers from pvc infusion medical devices |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825016/ https://www.ncbi.nlm.nih.gov/pubmed/29474357 http://dx.doi.org/10.1371/journal.pone.0192369 |
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