Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling

Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key role in the regulation of β-cell survival, functio...

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Detalles Bibliográficos
Autores principales: Zhang, Yun, Warnock, Garth L., Ao, Ziliang, Park, Yoo Jin, Safikhan, Nooshin, Ghahary, Aziz, Marzban, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825069/
https://www.ncbi.nlm.nih.gov/pubmed/29474443
http://dx.doi.org/10.1371/journal.pone.0193184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825069/
https://www.ncbi.nlm.nih.gov/pubmed/29474443
http://dx.doi.org/10.1371/journal.pone.0193184

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