Cargando…

Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling

Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key role in the regulation of β-cell survival, functio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yun, Warnock, Garth L., Ao, Ziliang, Park, Yoo Jin, Safikhan, Nooshin, Ghahary, Aziz, Marzban, Lucy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825069/ https://www.ncbi.nlm.nih.gov/pubmed/29474443 http://dx.doi.org/10.1371/journal.pone.0193184

Ejemplares similares

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets
por: Hui, Queenie, et al.
Publicado: (2017)

B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies
por: Wang, Xiaojie, et al.
Publicado: (2011)

Local Expression of Indoleamine 2,3 Dioxygenase in Syngeneic Fibroblasts Significantly Prolongs Survival of an Engineered Three-Dimensional Islet Allograft
por: Jalili, Reza B., et al.
Publicado: (2010)

Statistical approaches and software for clustering islet cell functional heterogeneity
por: Wills, Quin F., et al.
Publicado: (2016)

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
por: Marzban, Lucy, et al.
Publicado: (2008)

The Amyloid Forming Peptides Islet Amyloid Polypeptide and Amyloid β Interact at the Molecular Level
por: Wang, Ye, et al.
Publicado: (2021)

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
por: Mirecka, Ewa A., et al.
Publicado: (2016)

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045—3055
por: Marzban, Lucy, et al.
Publicado: (2016)

Feasibility of Amylin Imaging in Pancreatic Islets with β-Amyloid Imaging Probes
por: Yoshimura, Masashi, et al.
Publicado: (2014)

Phosphorylation modifies the molecular stability of β-amyloid deposits
por: Rezaei-Ghaleh, Nasrollah, et al.
Publicado: (2016)

IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation
por: Morikawa, Shinnosuke, et al.
Publicado: (2018)

Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins
por: Orr, Asuka A., et al.
Publicado: (2018)

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc
por: Wu, Xinghuo, et al.
Publicado: (2019)

Improving Islet Engraftment by Gene Therapy
por: Wang, Xiaojie, et al.
Publicado: (2011)

Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia
por: Ledo, Jose Henrique, et al.
Publicado: (2020)

Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease
por: Raimundo, Ana F., et al.
Publicado: (2020)

Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT
por: Cuddy, Leah K., et al.
Publicado: (2017)

Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice
por: Rezania, Alireza, et al.
Publicado: (2012)

Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation
por: Zatsepina, O. G., et al.
Publicado: (2018)

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
por: Sellers, Katherine J., et al.
Publicado: (2018)

Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species
por: Pilkington, Emily H., et al.
Publicado: (2016)

Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction
por: Rodríguez-Comas, Júlia, et al.
Publicado: (2020)

β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation
por: Lesma, Jacopo, et al.
Publicado: (2021)

Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
por: Wang, Xiaojie, et al.
Publicado: (2012)

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis
por: Xu, Jie, et al.
Publicado: (2021)

Immunotherapy for the treatment of Alzheimer’s disease: amyloid-β or tau, which is the right target?
por: Castillo-Carranza, Diana L, et al.
Publicado: (2013)

IL-6 Promotes Islet β-Cell Dysfunction in Rat Collagen-Induced Arthritis
por: Jin, Huan, et al.
Publicado: (2016)

Phosphorylation of covalent organic framework nanospheres for inhibition of amyloid-β peptide fibrillation
por: Yao, Linli, et al.
Publicado: (2022)

Matrix Development for the Detection of Phosphorylated Amyloid-β Peptides by MALDI-TOF-MS
por: Liepold, Thomas, et al.
Publicado: (2023)

Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy
por: Aroor, Alisha, et al.
Publicado: (2023)

Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide
por: Ahrén, Bo, et al.
Publicado: (2008)

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients
por: Kamata, Kosuke, et al.
Publicado: (2014)

Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils
por: Wang, Shih-Ting, et al.
Publicado: (2017)

Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet β-cell
por: Kowluru, Anjaneyulu
Publicado: (2008)

Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders
por: Batarseh, Yazan S., et al.
Publicado: (2016)

Lipid Modulation in the Formation of β-Sheet Structures. Implications for De Novo Design of Human Islet Amyloid Polypeptide and the Impact on β-Cell Homeostasis
por: Martínez-Navarro, Israel, et al.
Publicado: (2020)

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains
por: Tamayev, Robert, et al.
Publicado: (2009)

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production
por: Rezai-Zadeh, Kavon, et al.
Publicado: (2009)

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity
por: Kumar, Sathish, et al.
Publicado: (2016)

Kinetics of the Interactions between Copper and Amyloid‐β with FAD Mutations and Phosphorylation at the N terminus
por: Girvan, Paul, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_csqj03v8vmge1q7uhtkkjsavhs