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Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia

T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation...

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Detalles Bibliográficos
Autores principales:	Kulling, Paige M., Olson, Kristine C., Hamele, Cait E., Toro, Mariella F., Tan, Su-Fern, Feith, David J., Loughran, Thomas P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825082/ https://www.ncbi.nlm.nih.gov/pubmed/29474442 http://dx.doi.org/10.1371/journal.pone.0193429

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