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Same but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains

The majority of the proteins encoded in the genomes of eukaryotes contain more than one domain. Reasons for high prevalence of multi-domain proteins in various organisms have been attributed to higher stability and functional and folding advantages over single-domain proteins. Despite these advantag...

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Detalles Bibliográficos
Autores principales: Vishwanath, Sneha, de Brevern, Alexandre G., Srinivasan, Narayanaswamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825166/
https://www.ncbi.nlm.nih.gov/pubmed/29432415
http://dx.doi.org/10.1371/journal.pcbi.1006008