Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies

The commercial success of bispecific antibodies generally has been hindered by the complexities associated with generating appropriate molecules for both research scale and large scale manufacturing purposes. Bispecific IgG (BsIgG) based on two antibodies that use an identical common light chain can...

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Detalles Bibliográficos
Autores principales: Van Blarcom, Thomas, Lindquist, Kevin, Melton, Zea, Cheung, Wai Ling, Wagstrom, Chris, McDonough, Dan, Valle Oseguera, Cendy, Ding, Sheng, Rossi, Andrea, Potluri, Shobha, Sundar, Purnima, Pitts, Steven, Sirota, Marina, Galindo Casas, Meri, Yan, Yu, Jones, Jeffrey, Roe-Zurz, Zygy, Srivatsa Srinivasan, Surabhi, Zhai, Wenwu, Pons, Jaume, Rajpal, Arvind, Chaparro-Riggers, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825193/
https://www.ncbi.nlm.nih.gov/pubmed/29227213
http://dx.doi.org/10.1080/19420862.2017.1406570

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