Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function

Novel biotherapeutic glycoproteins, like recombinant monoclonal antibodies (mAbs) are widely used for the treatment of numerous diseases. The N-glycans attached to the constant region of an antibody have been demonstrated to be crucial for the biological efficacy. Even minor modifications of the N-g...

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Detalles Bibliográficos
Autores principales: Popp, Oliver, Moser, Samuel, Zielonka, Jörg, Rüger, Petra, Hansen, Silke, Plöttner, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825202/
https://www.ncbi.nlm.nih.gov/pubmed/29173063
http://dx.doi.org/10.1080/19420862.2017.1405203

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