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Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

Mammalian sirtuin 6 (Sirt6) is a conserved NAD(+)-dependent deacylase and mono-ADP ribosylase that is known to be involved in DNA damage repair, metabolic homeostasis, inflammation, tumorigenesis, and aging. Loss of Sirt6 in mice results in accelerated aging and premature death within a month. Here,...

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Detalles Bibliográficos
Autores principales:	Ghosh, Shrestha, Wong, Sheung Kin, Jiang, Zhixin, Liu, Baohua, Wang, Yi, Hao, Quan, Gorbunova, Vera, Liu, Xinguang, Zhou, Zhongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825207/ https://www.ncbi.nlm.nih.gov/pubmed/29474172 http://dx.doi.org/10.7554/eLife.32127

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