Cargando…
The soluble guanylate cyclase stimulator IW‐1973 prevents inflammation and fibrosis in experimental non‐alcoholic steatohepatitis
BACKGROUND AND PURPOSE: Non‐alcoholic steatohepatitis (NASH) is the hepatic manifestation of metabolic syndrome and is characterized by steatosis, inflammation and fibrosis. Soluble guanylate cyclase (sGC) stimulation reduces inflammation and fibrosis in experimental models of lung, kidney and heart...
Autores principales: | Flores‐Costa, Roger, Alcaraz‐Quiles, José, Titos, Esther, López‐Vicario, Cristina, Casulleras, Mireia, Duran‐Güell, Marta, Rius, Bibiana, Diaz, Alba, Hall, Katherine, Shea, Courtney, Sarno, Renee, Currie, Mark, Masferrer, Jaime L, Clària, Joan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825296/ https://www.ncbi.nlm.nih.gov/pubmed/29281143 http://dx.doi.org/10.1111/bph.14137 |
Ejemplares similares
-
Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit
por: Flores-Costa, Roger, et al.
Publicado: (2020) -
Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
por: López-Vicario, Cristina, et al.
Publicado: (2017) -
The discovery and characterization of novel soluble guanylate cyclase stimulators
por: Masferrer, Jaime L
Publicado: (2015) -
The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
por: Ge, Pei, et al.
Publicado: (2016) -
New Insights into the Role of Macrophages in Adipose Tissue Inflammation and Fatty Liver Disease: Modulation by Endogenous Omega-3 Fatty Acid-Derived Lipid Mediators
por: Clària, Joan, et al.
Publicado: (2011)