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Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types
Quantitative mismatches between human physiology and experimental models can be problematic for the development of effective therapeutics. When the effects of drugs on human adult cardiac electrophysiology are of interest, phenotypic differences with animal cells, and more recently stem cell-derived...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825396/ https://www.ncbi.nlm.nih.gov/pubmed/29507757 http://dx.doi.org/10.1038/s41540-018-0047-2 |