Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection

Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS res...

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Detalles Bibliográficos
Autores principales: Lwin, Nilar, Boyle, Michael, Davis, Joshua S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825900/
https://www.ncbi.nlm.nih.gov/pubmed/29507866
http://dx.doi.org/10.1093/ofid/ofy027
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author Lwin, Nilar
Boyle, Michael
Davis, Joshua S
author_facet Lwin, Nilar
Boyle, Michael
Davis, Joshua S
author_sort Lwin, Nilar
collection PubMed
description Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab.
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spelling pubmed-58259002018-03-05 Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection Lwin, Nilar Boyle, Michael Davis, Joshua S Open Forum Infect Dis Brief Report Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab. Oxford University Press 2018-01-30 /pmc/articles/PMC5825900/ /pubmed/29507866 http://dx.doi.org/10.1093/ofid/ofy027 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Lwin, Nilar
Boyle, Michael
Davis, Joshua S
Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection
title Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection
title_full Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection
title_fullStr Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection
title_full_unstemmed Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection
title_short Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection
title_sort adalimumab for corticosteroid and infliximab-resistant immune reconstitution inflammatory syndrome in the setting of tb/hiv coinfection
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825900/
https://www.ncbi.nlm.nih.gov/pubmed/29507866
http://dx.doi.org/10.1093/ofid/ofy027
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AT davisjoshuas adalimumabforcorticosteroidandinfliximabresistantimmunereconstitutioninflammatorysyndromeinthesettingoftbhivcoinfection

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