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Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease

OBJECTIVES: Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) have some overlapping clinical features, i.e. gut and joint inflammation. Cytokines of interleukin 17(IL-17)/IL-23 axis play a pathogenic role in both diseases. Integrins (ITGs) regulate migration of immune cells to inflamed ti...

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Autores principales: Kontny, Ewa, Dmowska-Chalaba, Joanna, Kwiatkowska, Brygida, Maśliński, Włodzimierz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825965/
https://www.ncbi.nlm.nih.gov/pubmed/29491535
http://dx.doi.org/10.5114/reum.2017.72624
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author Kontny, Ewa
Dmowska-Chalaba, Joanna
Kwiatkowska, Brygida
Maśliński, Włodzimierz
author_facet Kontny, Ewa
Dmowska-Chalaba, Joanna
Kwiatkowska, Brygida
Maśliński, Włodzimierz
author_sort Kontny, Ewa
collection PubMed
description OBJECTIVES: Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) have some overlapping clinical features, i.e. gut and joint inflammation. Cytokines of interleukin 17(IL-17)/IL-23 axis play a pathogenic role in both diseases. Integrins (ITGs) regulate migration of immune cells to inflamed tissues (ITGβ7 into gut, ITGβ2 into gut and also to other tissues). In this study, we search for differences in the serum concentrations of these cytokines and integrins between patients suffering from SpA or IBD with and without overlapping symptoms. MATERIAL AND METHODS: Patients with SpA (n = 30), IBD (n = 68), and healthy volunteers (n = 28) were included in the study. Fourteen SpA patients reported symptoms characteristic for IBD. Spondyloarthritis symptoms were diagnosed in 50% of IBD patients, while other patients of this group reported arthralgia only. Serum concentrations of IL-17, IL-22, IL-23, ITGβ2, and ITGβ7 were measured by specific enzyme-linked immunosorbent assay using commercially available sets. The Mann-Whitney and Spearman’s rank tests were used for intergroup comparison and correlation assessment, respectively. RESULTS: Comparison of patient groups showed significantly higher serum concentrations of IL-17, IL-22, and ITGβ7 in SpA, and up-regulated levels of IL-23 in IBD patients. Similar differences were observed between patient subgroups, both with and without overlapping symptoms. In SpA but not in IBD patients, serum concentrations of ITGβ7 inversely correlated (r = –0.552) with C-reactive protein. CONCLUSIONS: Patients with SpA and IBD differ in the circulating concentrations of IL-17/IL-23 axis cytokines and ITGβ7, irrespectively of the presence or absence of overlapping symptoms. Therefore, we conclude that observed differences are attributed rather to underlying than concurrent disease.
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spelling pubmed-58259652018-02-28 Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease Kontny, Ewa Dmowska-Chalaba, Joanna Kwiatkowska, Brygida Maśliński, Włodzimierz Reumatologia Original Paper OBJECTIVES: Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) have some overlapping clinical features, i.e. gut and joint inflammation. Cytokines of interleukin 17(IL-17)/IL-23 axis play a pathogenic role in both diseases. Integrins (ITGs) regulate migration of immune cells to inflamed tissues (ITGβ7 into gut, ITGβ2 into gut and also to other tissues). In this study, we search for differences in the serum concentrations of these cytokines and integrins between patients suffering from SpA or IBD with and without overlapping symptoms. MATERIAL AND METHODS: Patients with SpA (n = 30), IBD (n = 68), and healthy volunteers (n = 28) were included in the study. Fourteen SpA patients reported symptoms characteristic for IBD. Spondyloarthritis symptoms were diagnosed in 50% of IBD patients, while other patients of this group reported arthralgia only. Serum concentrations of IL-17, IL-22, IL-23, ITGβ2, and ITGβ7 were measured by specific enzyme-linked immunosorbent assay using commercially available sets. The Mann-Whitney and Spearman’s rank tests were used for intergroup comparison and correlation assessment, respectively. RESULTS: Comparison of patient groups showed significantly higher serum concentrations of IL-17, IL-22, and ITGβ7 in SpA, and up-regulated levels of IL-23 in IBD patients. Similar differences were observed between patient subgroups, both with and without overlapping symptoms. In SpA but not in IBD patients, serum concentrations of ITGβ7 inversely correlated (r = –0.552) with C-reactive protein. CONCLUSIONS: Patients with SpA and IBD differ in the circulating concentrations of IL-17/IL-23 axis cytokines and ITGβ7, irrespectively of the presence or absence of overlapping symptoms. Therefore, we conclude that observed differences are attributed rather to underlying than concurrent disease. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2017-12-30 2017 /pmc/articles/PMC5825965/ /pubmed/29491535 http://dx.doi.org/10.5114/reum.2017.72624 Text en Copyright: © 2017 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Kontny, Ewa
Dmowska-Chalaba, Joanna
Kwiatkowska, Brygida
Maśliński, Włodzimierz
Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease
title Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease
title_full Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease
title_fullStr Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease
title_full_unstemmed Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease
title_short Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease
title_sort cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825965/
https://www.ncbi.nlm.nih.gov/pubmed/29491535
http://dx.doi.org/10.5114/reum.2017.72624
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