Cargando…

Significance and In Vivo Detection of Iron-Laden Microglia in White Matter Multiple Sclerosis Lesions

Microglia are resident immune cells that fulfill protective and homeostatic functions in the central nervous system (CNS) but may also promote neurotoxicity in the aged brain and in chronic disease. In multiple sclerosis (MS), an autoimmune demyelinating disease of the CNS, microglia and macrophages...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gillen, Kelly M., Mubarak, Mayyan, Nguyen, Thanh D., Pitt, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826076/ https://www.ncbi.nlm.nih.gov/pubmed/29515576 http://dx.doi.org/10.3389/fimmu.2018.00255

Ejemplares similares

QSM is an imaging biomarker for chronic glial activation in multiple sclerosis lesions
por: Gillen, Kelly M., et al.
Publicado: (2021)

Microglia activation in periplaque white matter in multiple sclerosis depends on age and lesion type, but does not correlate with oligodendroglial loss
por: Kessler, Wiebke, et al.
Publicado: (2023)

Aged lipid‐laden microglia display impaired responses to stroke
por: Arbaizar‐Rovirosa, Maria, et al.
Publicado: (2022)

Vasomotor reactivity comparison in multiple sclerosis patients with white matter lesions and nonmultiple sclerosis subjects with white matter lesions in brain magnetic resonance imaging
por: Khorvash, Fariborz, et al.
Publicado: (2016)

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
por: Ponath, Gerald, et al.
Publicado: (2018)

Longitudinal analysis of white matter and cortical lesions in multiple sclerosis
por: Fartaria, Mário João, et al.
Publicado: (2019)

Mapping the relationship of white matter lesions to depression in multiple sclerosis
por: Baller, Erica B., et al.
Publicado: (2023)

Correlation between white matter damage and gray matter lesions in multiple sclerosis patients
por: Han, Xue-mei, et al.
Publicado: (2017)

Increased HLA-E expression in white matter lesions in multiple sclerosis
por: Durrenberger, Pascal F, et al.
Publicado: (2012)

White matter lesion location correlates with disability in relapsing multiple sclerosis
por: Gaetano, Laura, et al.
Publicado: (2020)

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
por: van der Poel, Marlijn, et al.
Publicado: (2019)

Decoding Diffusivity in Multiple Sclerosis: Analysis of Optic Radiation Lesional and Non-Lesional White Matter
por: Klistorner, Alexander, et al.
Publicado: (2015)

Geostatistical Analysis of White Matter Lesions in Multiple Sclerosis Identifies Gender Differences in Lesion Evolution
por: Marschallinger, Robert, et al.
Publicado: (2018)

Comparative Aspects of Microglia Reaction in White and Gray Matter
por: Cătălin, B., et al.
Publicado: (2013)

Unique microglia expression profile in developing white matter
por: Staszewski, Ori, et al.
Publicado: (2019)

Heterogeneity of microglia and their differential roles in white matter pathology
por: Lee, Janice, et al.
Publicado: (2019)

Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions
por: Mehta, Veela, et al.
Publicado: (2013)

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients
por: Droby, Amgad, et al.
Publicado: (2015)

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients
por: van Nierop, Gijsbert P., et al.
Publicado: (2017)

Neuroradiological differentiation of white matter lesions in patients with multiple sclerosis and Fabry disease
por: Rath, Jakob, et al.
Publicado: (2022)

Clinical Significance of White Matter Lesions in Idiopathic Sudden Sensorineural Hearing Loss
por: Shin, Seung-Ho, et al.
Publicado: (2022)

Relationship Between White Matter Lesions and Gray Matter Atrophy in Multiple Sclerosis: A Systematic Review
por: Lie, Ingrid Anne, et al.
Publicado: (2022)

Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers
por: Bussas, Matthias, et al.
Publicado: (2021)

Loss of USP18 in microglia induces white matter pathology
por: Schwabenland, Marius, et al.
Publicado: (2019)

Tissue Transglutaminase Appears in Monocytes and Macrophages but Not in Lymphocytes in White Matter Multiple Sclerosis Lesions
por: Chrobok, Navina L, et al.
Publicado: (2019)

Abnormalities in normal-appearing white matter from which multiple sclerosis lesions arise
por: Elliott, Colm, et al.
Publicado: (2021)

Accumulation of meningeal lymphocytes correlates with white matter lesion activity in progressive multiple sclerosis
por: Ahmed, Shanzeh M., et al.
Publicado: (2022)

Neurite density of white matter significantly correlates with tuberous sclerosis complex disease severity
por: Anaby, Debbie, et al.
Publicado: (2022)

Iba-1(-)/CD68(+) microglia are a prominent feature of age-associated deep subcortical white matter lesions
por: Waller, Rachel, et al.
Publicado: (2019)

MSCs-laden injectable self-healing hydrogel for systemic sclerosis treatment
por: Nie, Min, et al.
Publicado: (2022)

Ultrastructural pathology of oligodendrocytes adjacent to microglia in prefrontal white matter in schizophrenia
por: Uranova, Natalya A., et al.
Publicado: (2018)

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories
por: Gefen, Tamar, et al.
Publicado: (2019)

The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia
por: Sirkis, Daniel W, et al.
Publicado: (2021)

FLAIR* to visualize veins in white matter lesions: A new tool for the diagnosis of multiple sclerosis?
por: Campion, T., et al.
Publicado: (2017)

Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis
por: Elkjaer, Maria L., et al.
Publicado: (2019)

Expression of disease‐related miRNAs in white‐matter lesions of progressive multiple sclerosis brains
por: Tripathi, Ajai, et al.
Publicado: (2019)

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis
por: Elliott, Colm, et al.
Publicado: (2019)

Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis
por: Elkjaer, Maria L., et al.
Publicado: (2019)

Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or naïve notion?
por: Pongratz, Viola, et al.
Publicado: (2019)

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
por: Miedema, Anneke, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o7mpoptodcgegjumt39a8mkfb0